Yes, you can use toluene, benzene, xylene, either. They will not be distilled with the solvent because their boiling point is higher than that of the solvent. You can directly enter the hydrogen chloride gas after drying, without affecting it.
After the extraction is completed, keep your toluene solution, and add sodium sulfate to the solution to dry. Filter, then put hydrogen chloride gas into the solution, and the white powder is your product.
Just now, a magical thing happened. After drying the toluene solution, hydrogen chloride was introduced, leaving less than 0.5 grams of powder. However, when I filtered the original solution, it turned back into pseudoephedrine
After heating and refluxing, add 20ml of water first, then adjust the pH value of the alkali to above 10, then add sodium thiosulfate, and then use toluene for extraction instead of dcm. Is there any mistake in these procedures at present?
Great workup, thanks for sharing. Been do this type of reduction twice, first exactly like the writeup ephedrine firs followed by h3po2 then iodine and its really intense reaction. Reflux for 6 hours and only get about 33% yield.
The second is i make the hi first in boiling flask by mixing iodine to h3po2 under cold condition. then pour the ephedrine, this way its not so intense like the first, reflux for about 8 hours and i get about 51 % yield