SGT-263: Comprehensive Insights and User Experiences

Exploring SGT-263: A Comprehensive Guide

In the ever-evolving landscape of synthetic cannabinoids, SGT-263 has gained attention as a novel compound with potential recreational and research applications. This guide provides insights into SGT-263.

Introduction to SGT-263

SGT-263, sometimes known as CUMYL-5F-P7AICA, is a synthetic cannabinoid that belongs to the indazole-3-carboxamide family. Like other synthetic cannabinoids, it has gained popularity for its potential psychoactive effects. SGT-263 is a synthetic compound that interacts with the endocannabinoid system (CB1 and CB2 receptors) in the human body. It is structurally related to other synthetic cannabinoids, which are designed to mimic the effects of natural cannabinoids like THC.

4-AcO-DMT Synthesis Reagents:

• 1H-pyrrolo[2, 3-b]pyridine-3-carboxylic acid (0.49 g, 3 mmol);
• Oxalyl chloride (0.6 mL, 7.2 mmol);
• DMF (2 mL);
• Dichloromethane (42 mL);
• Methanol (30 mL);
• Saturated sodium bicarbonate (NaHCO3) solution;
• Sodium sulphate (Na2SO4) anhydrous;
• Potassium t-butoxide (0.27 g, 2.4 mmol);
• 1-bromo-5-fluoropentane (1.6 g,9.5 mmol);
• THF (25 mL);
• Ethyl acetate;
• Brine (NaCl aq) solution;
• Silica gel;
• n-Hexane;
• Sodium hydroxide (NaOH) solution (10 mL) 6 mol/L;
• Hydrochloric acid (HCl) 1 mol/L;
• Oxalyl chloride (3 mmol);
• Cumylamine (2 mmol);
• Triethylamine (0.5 mL);

SGT-263 Synthesis

1. A solution of 1H-pyrrolo[2, 3-b]pyridine-3-carboxylic acid (0.49 g, 3 mmol), oxalyl chloride (0.6 mL, 7.2 mmol), and DMF (1 mL) in dichloromethane (20 mL) are stirred for 20 min.
2. The mixture is evaporated and then redissolved in methanol (20 mL) and stirred for 40 min.
3. Then, the mixture is evaporated followed by extraction with ethyl acetate.
4. The organic phase is washed with a saturated sodium bicarbonate (NaHCO₃) solution and dried with Na₂SO₄, the solvent is removed in vacuo to yield the white solid (0.36 g, 68%).
5. A solution of Step 4 (0.36 g, 2 mmol), potassium t-butoxide (0.27 g, 2.4 mmol), and 1-bromo-5-fluoropentane (1.6 g, 9.5 mmol) in THF (20 mL) is stirred for 24 h.
6. The mixture is extracted with ethyl acetate.
7. The organic phase is washed with brine (NaCl aq) and dried with Na₂SO₄ (or Na₂SO₄), and the solvent is removed in vacuo.
8. The residue is purified by silica gel chromatography with stepwise gradient elution of n-hexane/ethyl acetate (3:1–2:1–1:1, v/v) to yield the white solid (0.35 g, 65%).
9. A solution of Step 8 (0.35 g, 1.3 mmol) and 6 mol/L sodium hydroxide solution (10 mL) in methanol/THF (2:1, v/v, 15 mL) is stirred for 1.5 days.
10. The mixture is evaporated, added to water, and then washed with ethyl acetate.
11. A solution of 1 mol/L hydrochloric acid was added to the aqueous phase, and the mixture is extracted with ethyl acetate.
12. The organic phase is washed with brine and dried with Na₂SO₄, and the solvent was removed in vacuo to yield the white solid (0.39 g, quant.)
13. A solution of Step 12 (0.39 g, 1.3 mmol), oxalyl chloride (3 mmol), and DMF (1 mL) in dichloromethane (12 mL) is stirred for 10 min.
14. The mixture is evaporated and then redissolved in dichloromethane (10 mL).
15. Cumylamine (2 mmol) and triethylamine (0.5 mL) are added into the solution and stirred for 15 h.
16. The mixture is evaporated and then extracted with ethyl acetate.
17. The organic phase is washed with 0.1 mol/L hydrochloric acid solution, then, by saturated sodium bicarbonate solution and brine, and then dried with Na₂SO₄, and the solvent is removed in vacuo to yield the white solid SGT-263 hydrochloride (0.37 g, 77%).

Conclusion

SGT-263 is a synthetic cannabinoid that has piqued the interest of both researchers and individuals seeking recreational experiences. However, it is essential to approach this compound with caution, emphasizing safety, responsible use, and compliance with relevant laws and regulations.