Hi Patton, thank you for clarifying this. My confusion came from the Erowid write-up where they suggest getting rid of the PEG by soaking the initial mixture in Toluene, so I started to wonder whether some of the PEG will remain in the Toluene.
Here is the right process in my understanding, please let me know if you`d change something.
1. adding alkaline solution to pH 13
2. extract with Toluene/other non-polar
3. discard the old water layer, then perhaps do a few water washes?
4. Add some clean water to the non-polar solvent
5. Acidify until pH 3 with dilute HCl
6. The Pseudo will migrate to the water phase as Pseudo-HCl salt
7. The Ibuprofen (now acidic) will precipitate in the water phase so in theory we have pretty clean pseudo in the water.
(8.) Perhaps the final cleaning should be an AB extraction with ether although this could decrease the yield.
Here is the right process in my understanding, please let me know if you`d change something.
1. adding alkaline solution to pH 13
2. extract with Toluene/other non-polar
3. discard the old water layer, then perhaps do a few water washes?
4. Add some clean water to the non-polar solvent
5. Acidify until pH 3 with dilute HCl
6. The Pseudo will migrate to the water phase as Pseudo-HCl salt
7. The Ibuprofen (now acidic) will precipitate in the water phase so in theory we have pretty clean pseudo in the water.
(8.) Perhaps the final cleaning should be an AB extraction with ether although this could decrease the yield.
- By Fedbaby074
A/b extraction probably the best option still not guaranteed
- By Urky
?so do you mean i should use A/B extraction for this whole procedure ?
my new plan is to firstly dissolve the pills in ethanol for 5-8 hours. (last time this teqniqe dissolved bot IBU and PSE but he weight of Modafen box is 24pcs and one pill contains 200mg Ibuprofen and 30mg of PSE. so at the beginning i started with 5500mg
After ethanol souk i just let them evaporate rdry in chill.....it was okayn and the most insteresting think was that i went from 5500a to like 1500-1700 mg but im reallz sure this this just pse, ibu and some few fillers.
and from this point im wondering.
SOOOO do you think this is going to work ?
1. soalking whole mass in ethanol for 5-8 hours
2. filtering the solution and keeping the luquid and discarding leftover gag
3.now it time to heat on rly low heat snd slowly avaporate until getting desired powder mix of PSE n IBU.
4.adding alkaline water until my solution reaches pH of 13.........adding alkaline solution to what? like soke pills in alkaline water ? because my pills contain shit that activates in water.
5. extract with toluene
6. now discard the old water layer, then perhaps do a few water washes?
7. Add some clean destilled water to the non-polar solvent
8. Acidify until pH 3 with dilute HCl (do i need to shake it, or just slow swirling is okey?)
9.The Pseudo will migrate to the water phase as Pseudo-HCl salt
10. The Ibuprofen (now acidic) will precipitate in the water phase so in theory we have pretty clean pseudo in the water
11. lastly i can do A/B extraction to purify the PSE even more.
Thanks for responses
my new plan is to firstly dissolve the pills in ethanol for 5-8 hours. (last time this teqniqe dissolved bot IBU and PSE but he weight of Modafen box is 24pcs and one pill contains 200mg Ibuprofen and 30mg of PSE. so at the beginning i started with 5500mg
After ethanol souk i just let them evaporate rdry in chill.....it was okayn and the most insteresting think was that i went from 5500a to like 1500-1700 mg but im reallz sure this this just pse, ibu and some few fillers.
and from this point im wondering.
SOOOO do you think this is going to work ?
1. soalking whole mass in ethanol for 5-8 hours
2. filtering the solution and keeping the luquid and discarding leftover gag
3.now it time to heat on rly low heat snd slowly avaporate until getting desired powder mix of PSE n IBU.
4.adding alkaline water until my solution reaches pH of 13.........adding alkaline solution to what? like soke pills in alkaline water ? because my pills contain shit that activates in water.
5. extract with toluene
6. now discard the old water layer, then perhaps do a few water washes?
7. Add some clean destilled water to the non-polar solvent
8. Acidify until pH 3 with dilute HCl (do i need to shake it, or just slow swirling is okey?)
9.The Pseudo will migrate to the water phase as Pseudo-HCl salt
10. The Ibuprofen (now acidic) will precipitate in the water phase so in theory we have pretty clean pseudo in the water
11. lastly i can do A/B extraction to purify the PSE even more.
Thanks for responses
