Full MDA Synthesis Starting from Helional

[Field7]

That's the "Two Dogs" method.

What's funny is that the hard part of this for me would be all the methylene chloride because it's no longer readily available for sale here because of it's toxicity. Can still get it, but now it's expensive and generates questions if bought in bulk.

I think I'd rather just reduce the oxime with sodium metal in anhydrous ethanol, and then take it from there.

 

[GhostChemist]

Use another extragent such as toluene, petroleum ether, diethyl ether, chloroform etc.

 

[Field7]

Yeah. But the idea is to rinse the solid product to remove some Xylene. Any remaining butane will evaporate quickly.

But again--- that little bit of Xylene may actually help the reaction along.

It's a toss up.

I think I'll try it without the butane rinse, first. It's less work, and if it goes well, then great.

I'll try that in the near future. Yes-- I'll share the results. 'Cause it's not just me that wants to avoid DCM.

 

[Field7]

I get that, but again--- I'm talking about what I think would be a small amount left over from the previous reaction.

Trying to avoid DCM and streamline the process.