Amfetamine synthese in één pot van P2NP met NaBH4/CuCl2 (schaal van 1 kg)

[Uncle Lee]

Deze reactie is heel goed op kleine schaal
In een grote reactie zal het proberen te controleren van de exotherm en de grote hoeveelheid schuim door de CuCl2-oplossing langzaam in de kolf te doen geen hoge opbrengst geven, er kunnen alleen maar nitroalkanen zijn en de concentratie nanodeeltjes zal te klein zijn om de nitro te reduceren, er moet een zo groot mogelijke kolf worden gebruikt en de volledige CuCl2-oplossing moet in één keer worden toegevoegd.

 

[waltjr5858]

But when you add all of the cucl2 at once the whole mixture turns black and then within minutes the catalyst falls out of the alcohol and doesn't do much down low... adding drop wise allows a continuous supply of copper to stay in the upper layer acting as a catalyst. So far I have found if you have too much nabh4 left at the time of adding the copper the copper gets reduced wayyy to fast and losses its catalyst activity instead of almost starting as a yellow or brown mixture and slowly turning black before finally falling to the bottom. Thise are the reactions that really work for me when the borohydride amount is low enough to not instantly reduce the copper to black and need the temperature increase to finally cause it to be fully reduced and settle in the bottom slowly over time.... but trying to get the perfect amount of nabh4 at that moment is let's say.... very difficult. Surprisingly the nitro doesn't need much nabh4 in the end to reduce.

 

[Mclssmxxl]

Kookplaat, verwarmingsmantel (kan te veel zijn, zelfs op laag), zeker geen open vuur.

 

[Johnny Ringo]

Was ist die beste low budget alternative zu einem 600€ heizmantel?

 

[btcboss2022]

100% zeker dat ik in grammen volgende batch foto's zal maken. Ik heb 254gr freebase uit 287gr P2NP.

 

[Johnny Ringo]

Wie viel war es in flüssiger form?

 

[Montecristo]

Ik kreeg niet veel zoutneerslag toen ik fosforzuur toevoegde aan mijn 67g p2np batch.
Zal dit veranderen tijdens het invriezen? Ik dacht dat ik de instructies goed had opgevolgd.
Ga je na het toevoegen van p2np meteen over op cucl of moet ik wachten tot het niet meer reageert?
Ik heb het na het toevoegen van de loog geschud en ongeveer een uur laten staan, en bij het extraheren met ipa heb ik het laten scheiden en toen 3/4 keer opnieuw gemengd.
Ik heb de ipa vacuüm gedestilleerd bij 50-60oC, was dit te heet?
misschien heb ik het te snel aangezuurd, want mijn sep funeel had nog steeds de waterige laag (ik doe 2 ipa extracties voor het geval dat) dus ik gebruikte een spuit en het was niet precies druppelsgewijs....
Iemand een idee? Ik zal een update geven nadat het een nacht in de vriezer heeft gelegen.

 

[Johnny Ringo]

Habe es auch versaut beim ersten mal gucke grad nach lösungen und schließe mögliche fehler aus. Hat sich bei dir auch nur ein kleiner teil umgewandelt und es ist größtenteils flüssig geblieben?

 

[pekonias]

Was your freebase purified? This reaction produces quite alot by-products so it's absolutely required to steam distill the freebase. Put 1ml freebase oil on petri dish and let evaporate. If the residue is not white it's not pure. If it's not pure and you turn it to salt, your power doesn't dissolve in water easily and yoy'll get sick if you take it.
So this was the boiling temp in the flask or bath temp? Not sure if too hot when I did it the BP was ~38 C while the water bath was kept < 60 C. (The BP only depends on pressure so higher bath temp. only makes it boil more violenly at same temp.) Do normal distillation of your vacuum distillate and see if anything solid remains in boil flask.
Might be dissolved in the water in it.

 

[Johnny Ringo]

Good to know the destillation is essential for this process thanks. I kept the oil and will try to purify it with destillation and see what comes out.

 

[Mclssmxxl]

Ik hoorde van patton hier dat je het eerst moet verwarmen. Iets wat ik nog nooit heb gedaan met zwavelzuur, maar mijn zuur is dan ook vrij zuiver.
Bestel uit Polen als je in de EU bent, ze verkopen je vaten van letterlijk alles lol

 

[Johnny Ringo]

Darfst du mir hier verraten woher du die schwefelsäure beziehst oder muss ich dir privat schreiben? Habe grad probleme welche zu beschaffen nur phosphorsäure iaz für mich aktuell laufend zugänglich.

 

[G.Patton]

Hello, if you wanna get answer, use English in this section please. You also can post your questions in Germany section in your native language.

 

[waltjr5858]

You will actually be surprised you do not need a very powerful pump and determining what suction you are running at is a pain in the ass. I actually have a very good vacuum gauge that I hook directly up to my system and test boiling temperatures of known substances and it's still a little all over the place. I think the best thing you can do is steam distillation If the product allows because it does come over nice and clean and then just dry it with potassium carbonate and you are in business. Definitely do not buy a rotary vein vacuum pump because I have destroyed probably five of those things. They are very powerful and I can boil water below room temperature easily but without inexpensive setup I do not have a way to regulate vacuum pressure. If you crack open a small leak on purpose to lower the pressure what that causes is air now flowing through the system instead of sitting at a vacuum which causes your product to go right into a trap or right into the vacuum pump and gone. Any kind of oil that can be steam distilled is absolutely worth the time it takes. If you definitely need vacuum they sell some on Amazon and they are called diaphragm pumps I believe and require no oil so there's no way for you to contaminate the vacuum pump when you do distillation. Just pump away and they definitely go low enough to let's say take a 200° C boiling temp and get it close to just a little over 100 so plenty low enough and definitely worth it over the rotary vein. I think they cost just a tiny bit extra nothing crazy. That was probably the best purchase I ever made as a vacuum pump after blowing up five of the other ones

 

[mile123]

I have question about vacuum distillation.

In order to achieve vacuum, my compressor has to run all the time to create good vacuum and tight sealing.

1. Is simple distillation with flask and reflux condenser fine or should I use fractional column like in alcohols, although in this video simple is enough

2. Does your IPA evaporate through vacuum pump instead in receiving flask since all air is sucked through vacuum out because unit runs all the time?

3. Why flasks need to be round bottomed, I have erlenmayer flask as receiving and I don't see reason why I should replace it with round bottom?

4. I also created moonshine, can you tell how to dillute % of ABV, water or distilled water makes it look less crystal clear.

Thanks

 

[dobrytowar55]

Hi. Can someone tell me what the cost of ingredients and equipment for producing 1kg is? I would be grateful if someone could tell me if it is enough to scaling up everything to get a larger amout or does that cause any discrepancies? Also can someone tell me what is the CAS of this final product?

 

[GhostChemist]

Find it in our Comercial Section

 

[OneTensionSkyRed]

It would be really REALLY great if someone could run a TLC analysis of the products from this reaction. I've read that NaBH4/Cu reduction mainly produces N-hydroxylamines instead of amines for alpha-alkyl nitrostyrenes. Because of similar melting points for their salts and similar boiling points, the only way to separate and identify N-OH-amphetamine is by chromatography. The N-OH product is also active as a stimulant but it is different to amphetamine. I wonder if this is really true.

 

[GhostChemist]

what source reports this information?
all compounds tested with qualitative and quantitative analysis
N-OH group can be formed as an intermediate compound if the experiment is not carried out correctly

 

[OneTensionSkyRed]

Yes, I should have probably researched this a little more before posting here, apologies. The source for this comes from amateur chemists and there aren't any official publications to support this

 

[Chemical Dream]

Is so much NaBH4 really necessary or is it excessive

 

[mile123]

Vacuum distillation can be avoided, final product may contain IPA, without NaBH4 you can't get final product at all. It is base ingredient along P2NP

 

[keras]

So. You get this pure amphetamine. How much would you cut it ? 1kg amph turn to 2kg ? Because amph cheap profit should come from cutting it or I am wrong?

 

[GhostChemist]

Our team is study science methods for obtain only pure individual substances. We do not support and do not give recommendations for dilution this compounds to increase mass, yields

 

[malignoalfa]

resultado de FTIR e GC-MS de amostra deste método.

 

[mile123]

Am I the only one who sees a lot of impurities here?

 

[adhdcurse]

Hello Guys. Can someone please post here what chemicals exactly form in each reaction, step by step. I am trying to understand each step. There are several steps where it is not documented what chemicals are actually created. I am trying to use a Chemical Reaction Simulator/Modelling Software, like Aspen Plus, HYSYS, COPASI, Chemcad, Matlab, Cantera, COCO etc.

 

[keras]

When added to fast cucl reaction overeacted and fumed spills came out. Got like grey clay inside how should we clean it looks like a bitch to clean

 

[waltjr5858]

Easy to clean.... just use hcl... an acid like that will dissolve and wash that copper away...