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I think the only shortcoming of this video is that it doesn't split the ephedrine because what you get is mixed ephedrine. I think no one in our forum is willing to split ephedrine and share the video. If someone does, he is a great chemist.
 
Thank you for another magnificent video recital. This forum is incredible. Good job people, keep going strong.
 
Can crystallization of methcationine be done with this method? If not, what method should we use?
 
I think the only shortcoming of this video is that it doesn't split the ephedrine because what you get is mixed ephedrine. I think no one in our forum is willing to split ephedrine and share the video. If someone does, he is a great chemist.
Make dl-methamphetamine freebase and seperate the isomers with taratic acid after.
 
You don't need to have 500 ml of water for 65 g of methcathinone hcl, you can use 100 ml and 50ml dcm and wash it 3x 50ml dcm
 
if somebody worry about smell dont need heat can put too freezer on the night crystal also get out
 
Make dl-methamphetamine freebase and seperate the isomers with taratic acid after.
Guys plant derived Ephedrine and PseudoEphedrine possess a D rotatory alpha carbon.

During our beloved reduction reaction the only variating chiral center is the beta one (losing the 4th substituent, the hydroxyl, to an Hydrogen, implies the disappearance of the chirality of carbon beta in M-AMP.
Why? Simply because instead of R'-CH-OH-R" (Eph/PseudoEph) it will just become a R'-CH2-R".

So in simpler terms the chirality of the beta carbon doesn't matter because the hydroxyl (-OH) found in Eph/PseudoEph is cleaved to yield enantiopure D-MethylAMP regardless.

Different story is when you build methylAmp from symmetric precursors (see the P2P, CH3NH2,... route).
So NO, ephedrine is not "mixed" unless you synthesize it rather than extracting from a plant matrix such as ephedra sinica since nature usually function with enantiomerically pure structures. A clear example is the one of aminoacids: all the nature ones are L-AA--> L-Arginine, L-Methionine, L-Tyrosine, L-Tryptophan,...

The only situation where you will get a racemix mixture is when you start from phenylacetone as main precursor (P2P) which also is the only situation where 2-3 Tartaric Acid optical resolutions makes sense (and would be desired) to pass from a D:L of around 50:50 sequentially to:

1. 50:50 --> 75:25 (D:L)
2. 75:25 --> 87.5:12.5 (D:L)
3. 87.5:12.5 —> 93.75:7.25 (D:L)

yes you can re-racemize L-MAMP with radical initiators like AIBN:
meth-graph_v7_0.png


theAlchemist
 

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Synthesis of Methcathinones
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