Synthesis of Methamphetamine from P2P and NaBH4 Reduction

[ImRegistered]

This calls for methylamine 40% while another post in forum uses aq 10%. Is one better than the other ?

Methamphetamine synthesis from P2P by NaBH4 reduction. Medium-Scale.

Introduction I represent to BB audience Methamphetamine synthesis method of 1-phenyl-2-propanon (P2P) reductive amination by NaBH4. Following method allows obtaining and large batches of product. The hardest problem of this method is the heat generating during exothermic reaction of imine...

bbgate.com

 

[The_Real_DEA_42069]

A Mol is a mol

 

[ImRegistered]

Why is isopropyl added to methylamine+meoh? I have not seen the use of this solvent in other similar write ups
(Link in above post)

 

[G.Patton]

Because it's needed to redissolve methylamine in IPA. It's a better option in compare with my write up cuz it allows to get rid of water and increase yield.

 

[Heligo554]

Assuming you inadvertently add too much NaBH4 at once and the temperature rises to 30C, is there any way to save it or do you have to restart in any case?
Yes I know I'm a complete idiot... I added another 300ml of IPA to dilute everything again and now it looks like at least something is happening again.

 

[G.Patton]

You need to avoid such temperature fluctuations cuz it reduces yield significantly. You can continue this batch. It's worth to get something instead of nothing.

 

[Amin. M]

Thank you for your efforts
How to turn the final product into a crystal?

 

[GhostChemist]

http://bbzzzsvqcrqtki6umym6itiixfhn...ne-crystallization-and-ice-manufacturing.465/

http://bbzzzsvqcrqtki6umym6itiixfhn...-crystal-methamphetamine-hydrochloride.10314/

http://bbzzzsvqcrqtki6umym6itiixfhn.../media/methamphetamine-recrystallization.103/

 

[Grubby]

I have not successfully made amphetamine. I would like to ask the master. Why can't we directly distill the product with the boiling point of free amphetamine after the NaBH4 reduction reaction is completed? I want to know the principle.

 

[chef learner]

I hope that one day you can get the answer and I can improve my knowledge

 

[GhostChemist]

you can`t obtain amphetamine in this synthesis
This topic dedicated Methamphetamine

 

[Acab1312]

I tested this method, which worked quite well at first. Each addition of NaBh4 produced a slight exothermic of 2-4 ° (8-12°)When I finished after about 6 hours, the temperature rose to 45° within 30 minutes, although cooling was done with -20°. I don't know the yield, I will report on this later. My question is how it is that the temperature rises so suddenly? How can I avoid it? It becomes difficult to scale if I have to wait 30 min every time NaBh4 is added. Can I change something about it or switch back to methanol.

 

[GhostChemist]

Freon cooling or using a chiller might be effective, but this is more suitable for large-scale production.

 

[Seekinglife01]

In stage 4, Fig 14, 10-20 ml of ethanol is rinsed from the distillation flask.
Can I use another solvent instead of ethanol like methanol or isopropanol?
Or can I use ethanol denatured, as cant get ethanol undenatured?

 

[GhostChemist]

Yes you can use another solvent

 

[megurine]

Can I mix sodium hydroxide with methylamine hydrochloride, water with isopropanol and then sodium sulfate to get an isopropanol solution of methylamine, because I only have methylamine hydrochloride?
And can you use sodium cyanoborohydride instead of sodium borohydride, and what do you need to be careful of, because what can you only buy sodium cyanoborohydride for

 

[G.Patton]

There is tutorial how to make methanol solution correctly.

http://bbzzzsvqcrqtki6umym6itiixfhni37ybtt7mkbjyxn2pgllzxf2qgyd.onion/threads/methylamine-freebase-solution-preparation.10551/

You can but you have to take into account that this substance produce prussic acid during the reaction. Prussic acid is hazardous substance and can kill you in case of PPE and well ventilation absence.

 

[B APPLE]

Teacher, may I ask if all the methylamine, isopropanol, silica gel, and sodium sulfate should be poured into the flask or filtered before pouring？

 

[GhostChemist]

fast filtered before pouring is better

 

[B APPLE]

Teacher, may I ask if the distillation of DCM fails if it is not distilled at 90-105 degrees?

 

[GhostChemist]

DCM have Boiling point 39.6 °C

 

[B APPLE]

Hello teacher, may I ask which step went wrong when adding hydrogen chloride to make my amphetamine turn black and then heat it to evaporate into a cake like substance？

 

[GhostChemist]

amphetamine?
This topic dedicated Methamphetamine