Syntese af amfetamin fra P2NP via SnCl2 og Zn

[Bigballen]

Hvor meget syre skal der tilsættes til sidst?

 

[blacky2340]

Hæld 10 ml acetone på 1 ml koncentreret 97%+ svovlsyre i forholdet 10:1. Brug en pipette eller sprøjte til at dryppe opløsningen langsomt ned, indtil pH 5,5 er nået. Hvis den er oversyret, tilsættes mere freebase, hvis den er meget oversyret og bliver til væske, tilsættes a/b og omkrystalliseres.

 

[ActionAyi]

Jeg har også tænkt på toulen, men jeg tror, at forskellen i densitet er for lav, er den ikke?

 

[G.Patton]

Hej, tak for din rapport! Den er virkelig interessant. 10 g amph-fri base giver 80,4 % udbytte, hvilket er ret godt. Hvor meget salt fik du?

 

[Eleusius_hive_reboot]

i just did this synthesis successfully ! (i was very astonished, that it works, like described...!)

i used 1,7g P2NP

- created sncl2 sol. from h202 and conc HCL first, until total dissolution, quenched oxidizing agent w. Bisulfite.

- dissolved p2np in acetone / EtoH and brought solutions of sncl2/p2np-solvent together in 250ml RBF

vigourously stirred for 2hrs.

------SKIPPED OXIME ISOLATION !!!!! -----

instead gave antoher dash of conc. HCL in to the whole

and gave finely divided active-C powder a hydrogen absorber in to RM.

then three portions of Zn-dust were introduced in several heaps...with subsequent hcl/EtoH addition.

as the reagents were used up i gave a small am. of AcOH to the whole and let it further react out a 15mins.


- now i slowly alkalized to ph 12 (metal precipitates formed immediate and sank...no hassle in base extraction....did with xylene/pet.ether/naphta mixture (+a small emulsion preventing splash of 2-propanol , every extraction step...)


i pooled organic xtracts, washed them with conc.brine f. rocksalt....)

afterwards the washed org.phases were run trough fine filtering apparatus.

added a 100mls of H20 and then titrated with Hcl until ph 5,5 ~


the acidic solution was equiv. mixed with acetone / ethanol-2propanol

with concentration under stirring with surface vent.

then the pasty residue was further refined...

I OBTAINED almost 1,3g amph-hcl (hygroscopic but useable!)

so that is a fine well thought route to go, THANKS TO ORIGINAL MASTERMIND

 

[Eleusius_hive_reboot]

* MAJOR ! update:...

I DID ONE MORE "GOD-MOVE" AFTER THIS SURPRISE RESULT:.....

I SUCCEEDED IN MODIFYING THE SYNTHESIS - AND DID A REDUCTIVE AMINATION

WITH REFINED P2P AND METHYLAMMONIUMACETATE (OR KIND OF)

IT YIELDED METHAMPHETAMINE RACEMATE.... VERY UNEXPECTED QUANTITY- QUALITY AS SAME AS THE USUAL NABH4 ROUTE I PREFERRED BEFORE...


IT WENT DOWN FROM Imine formation -[ACIDIFIED VARIANT]...... TO HYDROCHLORIDE OF SLIGHT PINK APPEARANCE OVER NIGHT !

-->AT ROOM TEMPERATURE<----

PLEASE dont be mad at me but i decided to keep specifics for myself**

it is a whole new approach to phenetylamine syntheses in general ....

CREDITS TO THIS COMMUNITY PRO INSTRUCTIONAL P2P PURIFICATION TUTORIALS / I WENT TROUGH THE HASSLE OF THE WHOLE WORKUP TECHNIQUES OF THE BB-gate wisdom ...

THE PHENYLACETONE I DERIVED BY : Fe/H+ --P2NP---> Phenyl-2-Propanone


**(exception 4 you, Patton ..i made a writeup , documenting specs etc. i think you get what these
synthesis-dynamic principles hold in value )

 

[TucoSalamanca.]

Jeg fik 5 gram amfetamin ud af 15 gram p2np.

 

[Chemdogkm]

u recomend this reaction? Or the aluminum? Or the copper?

 

[sandman]

Jeg tror ikke, at det her virker. Jeg håber, det gør, og bliver nødt til at prøve det.

 

[TucoSalamanca.]

Jeg håber, det lykkes for dig, jeg fejlede.

 

[TucoSalamanca.]

Har du prøvet denne metode?

 

[mithyl2]

Jeg har prøvet borhydridmetoden mange gange uden held. det tætteste, jeg kom, var et udbytte på ca. 0,2 % amfetamin. det var dog ægte. jeg har virkelig brug for, at det virker, og det driver mig til vanvid. lad os høre, hvordan det går med dcm'en.

 

[TucoSalamanca.]

Jeg vil skrive, min ven, gå ikke glip af dine bønner, så denne syntese kan realiseres, tak.

 

[TucoSalamanca.]

Jeg kunne ikke syntetisere i dag, men jeg gør det i morgen og rapporterer tilbage.

 

[ActionAyi]

Er der nogen anden måde at lave ekstrakt på end DCM?
Måske n-hexan?

 

[August]

Hej venner, producerer denne reaktion ikke bare phenylethylamin (PEA), eller er jeg bare dum (stærk mulighed)?

 

[William D.]

Part of this method allows you to get phenylacetone. But stage 2 can be difficult.

 

[Amin. M]

Hej min ven
Jeg læste din kommentar og nød den
Hvordan fik du ren amfetamin (i det andet trin)?
Giv venligst råd om, hvilken metode til at producere amfetamin der er bedre og i sidste ende har en højere procentdel af renhed
Og at han skaffede råvarerne gennem butikken
(Jeg har ikke et professionelt laboratorium)

 

[michelAMPH]

Zonder de kosten van 300 gram P2NP .
alle grondstoffen voor 200 gram amfetamine free base kosten hier €416,68???
Mooi recept alleen het kan totaal niet uit