Why would one want to ruin 2cb? Nbome was a marketing tool IMO
Synthesis of 25B-NBOME from benzaldehydes with nitromethane
- Thread starter William D.
- Start date
Guess i'm just talking to myself but seems it would be easier to reduce the nitrostyrene strait to the 2,5 MO-PEA with Zn & HCl...
- By William D.
No, you cannot miss one step, having received an unsaturated substance or lose yield. Acetic acid with zinc in anhydrous conditions can work better. If only you do not take anhydrous HCl acid.
You arnt talking to yourself at all. This is very interesting article to me and one Iām gathering my supplies to try. I love the idea of having such a powerful psychedelic! Iād never be irresponsible with it and try to pass it of as acid - thatās what ruined these drugs in my opinion. It changed peopleās outlook on the nbomes when people started dying because the press only want a salacious story!
I personally ALWAYS dosed them responsibly and found them to be good psychedelics! Also having 2cb in the first place would be lovely, letās face it. I may have to buy 1/2kg of 2,5-dmo benzaldehyde. (Literally because I canāt find anyone I trust to sell me less than that!). There are so many diff things you can make with 2,5-dmo benzaldehyde though so even though there are more steps to the final product Iām after, than if I bought tryptamine, the fact is - there isnāt as much you can make with tryptamine that interests me as much as the phenethylamines - due to tollerence reasons, I prefer highly psychedelic phenethylamines, over tryptamines (in general - there are a few outliars tho).
Gotta love alibabaā¦
I personally ALWAYS dosed them responsibly and found them to be good psychedelics! Also having 2cb in the first place would be lovely, letās face it. I may have to buy 1/2kg of 2,5-dmo benzaldehyde. (Literally because I canāt find anyone I trust to sell me less than that!). There are so many diff things you can make with 2,5-dmo benzaldehyde though so even though there are more steps to the final product Iām after, than if I bought tryptamine, the fact is - there isnāt as much you can make with tryptamine that interests me as much as the phenethylamines - due to tollerence reasons, I prefer highly psychedelic phenethylamines, over tryptamines (in general - there are a few outliars tho).
Gotta love alibabaā¦
- By Sue
Try reading it may interst you?
SYNTHESIS OF N-(HALOGENATED) BENZYL ANALOGS OF SUPERPOTENT SEROTONIN LIGANDS
J. Chil. Chem. Soc., 59, NĀŗ 3 (2014)
In 2003, preliminary explorations led to the conclusion that N-2-
methoxybenzyl substitution, not only of phenylethylamines but also
phenylisopropylamines, tryptamines and 3-(2-aminoethyl)-(1H,3H)
quinazoline-2,4-diones related to the typical 5-HT2 receptor antagonist
ketanserin, results in particularly high affinities for 5-HT2A receptors.5
Everyone I know loves 25I over 25B and 25C it is a great psychedelic and easy on the mind...
SYNTHESIS OF N-(HALOGENATED) BENZYL ANALOGS OF SUPERPOTENT SEROTONIN LIGANDS
J. Chil. Chem. Soc., 59, NĀŗ 3 (2014)
In 2003, preliminary explorations led to the conclusion that N-2-
methoxybenzyl substitution, not only of phenylethylamines but also
phenylisopropylamines, tryptamines and 3-(2-aminoethyl)-(1H,3H)
quinazoline-2,4-diones related to the typical 5-HT2 receptor antagonist
ketanserin, results in particularly high affinities for 5-HT2A receptors.5
Everyone I know loves 25I over 25B and 25C it is a great psychedelic and easy on the mind...
- By Rabidreject
think I may have heard about this paper, Iāll have a lookā¦.
i know the chem is way over my head for the moment, in a practical sense.
Iām still trying to reduce the 3,4,5-TMONS I have made to the corresponding PEA. Iv managed it once in real bad yields via the NaBH4/CuCl2 method but not enough to use yet. I have a few different nitrostyreneās/nitropropeneās building up in my sample collection at the mo, I figured id work with the one I have most of until I get it right!
i know the chem is way over my head for the moment, in a practical sense.
Iām still trying to reduce the 3,4,5-TMONS I have made to the corresponding PEA. Iv managed it once in real bad yields via the NaBH4/CuCl2 method but not enough to use yet. I have a few different nitrostyreneās/nitropropeneās building up in my sample collection at the mo, I figured id work with the one I have most of until I get it right!
I'm having trouble getting 2-methoxybenzaldehyde for step 4, can it be replaced with 4-methoxybenzaldehyde or is there a recommendation for another compound?
- By tripeep
@WillD Hello sir, I'm having trouble getting 2-methoxybenzaldehyde for step 4, can it be replaced with 4-methoxybenzaldehyde or is there a recommendation for another compound?
- By HIGGS BOSSON
It will be an analogue of NBOme, with a lower psychoactive potency, but I think it will work. As an experiment, it can be synthesized, but the issue of biotests should be approached carefully at such low dosages of these compounds.
Issues i have with this:
Ā° i think you are attempting to form edda in situ from ethylene diamine and acetic acid? Probably works but its not worth the slightly lower yield for the minimal time saved.
Ā° amino acid catalysts produce far better yields for henrys (1)
Ā° WHAT EVEN IS THAT REDUCTION OF A NITROALKENE LMAOOOOO
makes no sense even in just grammatical terms 
Ā° nbs bromination is superior even bromination with bromine has always worked out better for me than hbr (anecdotal however check both the hive and the vesp)
Ā° Wtf is Et3N? im assuming triethylamine? what the fuck is that doing there lmao yeah it just doesnt need that X3(2)
Ā° 30mins to 3hrs? yeah 1.5hr is perfect(3)
Ā° This seems to literally just be scaled up without testing (although i somehow doubt op has any chem experience so i dont blame them) but this is a rather simple synthesis easily available online as either ralf hiems stuff, or the journal of chilean chemical society.
Ā° WAY WAY too fucking much ethylene diamine assuming a density of 0.9g per ml 200ml = 180g which = 2.995 moles assuming a 75% yield of EDDA in situ (hopeful thinking considering rhodium supposedly got that separately) we would achieve roughly 2.2 moles which is enough for 22moles subbed aldehyde
Ā° Some of my favourite quotes from here include :
"Extraction and distilled"
"500 g yellow oil (propane)"
ā240 g base yellow oil."
You should also note that salicylaldehyde is acceptable for instead producing NBOHs an easier to find precursor being found naturally too (meadowsweet) (it can also be prepared through reimer tiemann like 2-methoxy but have you ever tried one? They fucking suck bad yield dirty reaction)p
bai bai yall ^w^ <3 :3
(1) https://link.springer.com/article/10.1007/s10562-022-04228-4
(2) https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000300022 and page 233 of ralf hiems experimental
(3) page 233 of ralph hiems experimental (ss attached)
Ā° i think you are attempting to form edda in situ from ethylene diamine and acetic acid? Probably works but its not worth the slightly lower yield for the minimal time saved.
Ā° amino acid catalysts produce far better yields for henrys (1)
Ā° WHAT EVEN IS THAT REDUCTION OF A NITROALKENE LMAOOOOO
makes no sense even in just grammatical terms Ā° nbs bromination is superior even bromination with bromine has always worked out better for me than hbr (anecdotal however check both the hive and the vesp)
Ā° Wtf is Et3N? im assuming triethylamine? what the fuck is that doing there lmao yeah it just doesnt need that X3(2)
Ā° 30mins to 3hrs? yeah 1.5hr is perfect(3)
Ā° This seems to literally just be scaled up without testing (although i somehow doubt op has any chem experience so i dont blame them) but this is a rather simple synthesis easily available online as either ralf hiems stuff, or the journal of chilean chemical society.
Ā° WAY WAY too fucking much ethylene diamine assuming a density of 0.9g per ml 200ml = 180g which = 2.995 moles assuming a 75% yield of EDDA in situ (hopeful thinking considering rhodium supposedly got that separately) we would achieve roughly 2.2 moles which is enough for 22moles subbed aldehyde
Ā° Some of my favourite quotes from here include :
"Extraction and distilled"
"500 g yellow oil (propane)"
ā240 g base yellow oil."
You should also note that salicylaldehyde is acceptable for instead producing NBOHs an easier to find precursor being found naturally too (meadowsweet) (it can also be prepared through reimer tiemann like 2-methoxy but have you ever tried one? They fucking suck bad yield dirty reaction)p
bai bai yall ^w^ <3 :3
(1) https://link.springer.com/article/10.1007/s10562-022-04228-4
(2) https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000300022 and page 233 of ralf hiems experimental
(3) page 233 of ralph hiems experimental (ss attached)