Synthesis of 25B-NBOME from benzaldehydes with nitromethane

[fuqall]

Why would one want to ruin 2cb? Nbome was a marketing tool IMO

 

[Field7]

25B is a cool drug in its own right... at low doses. If you want an experience that's easy to manage out it public, it's a good one. Higher doses, it's not great, so for a "full on" experience, 2CB is the winner, there.

 

[Sue]

Guess i'm just talking to myself but seems it would be easier to reduce the nitrostyrene strait to the 2,5 MO-PEA with Zn & HCl...

 

[WillD]

No, you cannot miss one step, having received an unsaturated substance or lose yield. Acetic acid with zinc in anhydrous conditions can work better. If only you do not take anhydrous HCl acid.

 

[Sue]

Thank you will have to try using acidic acid in place of hydrochloride and see how it works...

 

[Rabidreject]

You arnt talking to yourself at all. This is very interesting article to me and one I’m gathering my supplies to try. I love the idea of having such a powerful psychedelic! I’d never be irresponsible with it and try to pass it of as acid - that’s what ruined these drugs in my opinion. It changed people’s outlook on the nbomes when people started dying because the press only want a salacious story!
I personally ALWAYS dosed them responsibly and found them to be good psychedelics! Also having 2cb in the first place would be lovely, let’s face it. I may have to buy 1/2kg of 2,5-dmo benzaldehyde. (Literally because I can’t find anyone I trust to sell me less than that!). There are so many diff things you can make with 2,5-dmo benzaldehyde though so even though there are more steps to the final product I’m after, than if I bought tryptamine, the fact is - there isn’t as much you can make with tryptamine that interests me as much as the phenethylamines - due to tollerence reasons, I prefer highly psychedelic phenethylamines, over tryptamines (in general - there are a few outliars tho).
Gotta love alibaba…

 

[Sue]

Try reading it may interst you?
SYNTHESIS OF N-(HALOGENATED) BENZYL ANALOGS OF SUPERPOTENT SEROTONIN LIGANDS
J. Chil. Chem. Soc., 59, Nº 3 (2014)

In 2003, preliminary explorations led to the conclusion that N-2-
methoxybenzyl substitution, not only of phenylethylamines but also
phenylisopropylamines, tryptamines and 3-(2-aminoethyl)-(1H,3H)
quinazoline-2,4-diones related to the typical 5-HT2 receptor antagonist
ketanserin, results in particularly high affinities for 5-HT2A receptors.5

Everyone I know loves 25I over 25B and 25C it is a great psychedelic and easy on the mind...

 

[Rabidreject]

think I may have heard about this paper, I’ll have a look….

i know the chem is way over my head for the moment, in a practical sense.

I’m still trying to reduce the 3,4,5-TMONS I have made to the corresponding PEA. Iv managed it once in real bad yields via the NaBH4/CuCl2 method but not enough to use yet. I have a few different nitrostyrene’s/nitropropene’s building up in my sample collection at the mo, I figured id work with the one I have most of until I get it right!

 

[Rabidreject]

Yeah. May take another year tho

 

[tripeep]

I'm having trouble getting 2-methoxybenzaldehyde for step 4, can it be replaced with 4-methoxybenzaldehyde or is there a recommendation for another compound?

 

[tripeep]

@WillD Hello sir, I'm having trouble getting 2-methoxybenzaldehyde for step 4, can it be replaced with 4-methoxybenzaldehyde or is there a recommendation for another compound?

 

[HerrHaber]

It's not the same at all and I think unsubstituted is better than 4, salycilaldehyde is easier to come across and also what I methylated to get my 2-methoxybenzaldehyde besides being of known activity.

 

[HIGGS BOSSON]

It will be an analogue of NBOme, with a lower psychoactive potency, but I think it will work. As an experiment, it can be synthesized, but the issue of biotests should be approached carefully at such low dosages of these compounds.