Syntheses of 2C-phenylethylamines

[NarwhalFucker419]

Does anyone have info on brominating 2C-H with n-bromosuccinimide? I've seen a few people mention it elsewhere but haven't found any writeups.

 

[Raxmil]

I'm looking for this too but I could not find the detailed information
What I know is you can do it in GAA or DCM but no idea about the ratio

 

[amieri]

There's a person in maybe theehive on Reddit.i believe the also have a mescaline synth posted too and a few others.

 

[btcboss2022]

I have a doubt over the last step of 2CB synth. It says "The reaction mixture was allowed to return to room temperature, filtered, and the solids washed sparingly with cold acetic acid" until I know acetic acid becomes solid at 16-17C so what means cold acetic acid exactly?
Thanks.

 

[G.Patton]

Hi. I'm assuming that the cold acid means room temperature because there is an explanation that the reaction releases heat.

 

[btcboss2022]

Ok ok I thought that too but I preferred to confirm as you know when we say cold normally we means from freezer not RT hahaha but with acetic acid is not possible ;-) thanks

 

[w2x3f5]

I don’t quite understand why washing amine hydrobromide, it’s impossible to use it, it burns. It is better to purify and get the hydrochloride and the losses are less, as to avoid dubious attempts to wash the powder from bromine.

 

[nujrc]

I understand that remaining elemental bromine is going to evaporate in the air from product, just like any solvent, so there won't be any reasonable amount left with time. Making HCL without drying HBr - good luck to get more pure product, because you may have to deal with bromine salts in bromine/GAA solution, and bromine itself.

 

[w2x3f5]

I don’t see any problems to beat the remains of bromine with thiosulfate, then bring the ph to an alkaline medium and collect the oil with a solvent.

 

[situ1984]

(R)-(+)-α-methylbenzylamine CAS number:
3886-69-9 Is it from the lungs? Or is it absorbed by the stomach? Can it be used directly?
(R)-(+)-α-methylbenzylamine CAS number:
3886-69-9 Is it from the lungs? Or is it absorbed by the stomach? Can it be used directly?

 

[G.Patton]

It has no psycho-effects.

 

[amieri]

Where does one get 2,5 dimethynitrostyrene

 

[HerrHaber]

Henry condensation of 2,5-dimethoxybenzaldehyde with nitromethane in presence of a primary amine as catalyst.

 

[amieri]

It blows my mind how far I've come in this since I wrote this . You guys are all works of inspiration thanks for sharing

 

[taricshop]

is it possible to replace elementar bromine with hbr acid? in 2cb synthesis?
@G.Patton

 

[Newbee]

@HEISENBERG @WillD @G.Patton
Question to you guys.Is it possible to perform bromination of 2ch to 2cb by NBS (N-Bromosuccinimide)
instead of elemental bromine (br2)

 

[G.Patton]

Hello.
Yes, I think so.

 

[amieri]

That's seems to be the new go to I see alot.i need to get some succinimide acid n give it a try.

 

[Newbee]

i found some writeups on thehivee but im not sure about it i also cant try do it on my own. but NBS seems to be safer to use than BR

 

[amieri]

I use a 2×2×4 grow tent in its side with a 8" inline fan going out the building as a hood up on a folding table definitely does the job,still wear a mask non the less. Make sure you have a 5% sodium thiosulphate solution on hand in case of a accident and a rubber made bin with enough of that solution to run through you glass at the end.and think every step out. You got this my friend can't wait to hear of your success.

 

[Swirly]

Yes, you can brominate with NBS on 2c-h HCl, you can read in my post.
You could even risk NBS bromination on 2c-h freebase in DCM or on the oxalate/sulfate salts.

Have a read:

https://bbgate.com/en-gb/threads/a-mostly-kitchen-friendly-synthesis-of-2c-b.13198/#post-73488

 

[amieri]

Sure you can, obviously dig as deep as you can researching hand but the fact you came this far says a lot.so keep pushing and if you waste something you at least gain the experience.now safety if thats what your concerned about thats a horse of a different color

 

[Rabidreject]

I just wanted to say thanks for this incredibly involved set of syntheses.
It is really impressive.
It’s funny, I made quite a few different nitrostyrene’s and nitropropene’s and then when I started reducing them and getting decent yields on active molecule’s, I started thinking okay, well it can’t be that much harder to produce the 2c-x compounds, then you see people making 2c-b and presumably other haloginated 2c’s and you think ah okay.

Then you start digging into the alkylated 2c compounds and my oh my does the chemistry take a jump in complexity!!

Anyway, I’m pretty convinced that my next major project is going to have to be the ethylated 4 position.
Is that a friedl-crafts alkylation you do to the 2,5-dimethoxyacetophenone, I mean in order to get from that to the 2,5-dimethoxy-1-ethylbenzene?

I think the most annoying part of it is that I’m going to have to get a vacuum pump that runs to super high vacuum!

Anyway, be prepared to be bugged by me a lot in the coming months/years because once I set my mind to something, I WILL learn how to get it done. It often involves harassing old posters! Ha