Product Name MYRISTICIN ALDEHYDE

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Product Name MYRISTICIN ALDEHYDE ZzUAKYP0m5

Chemical Properties​

Melting point130-132°C
Boiling point110-115 °C(Press: 0.5 Torr)
Density 1.321±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
form solid
Water Solubility Insoluble in water.
Sensitive Air Sensitive
BRN 384077
LogP1.310 (est)
CAS DataBase Reference5780-07-4(CAS DataBase Reference)
EPA Substance Registry System1,3-Benzodioxole-5-carboxaldehyde, 7-methoxy- (5780-07-4)
UNSPSC Code12352212

MYRISTICIN ALDEHYDE Price

Product number
PackagingPrice
Product description
Buy


Alfa Aesar
L08213
1g$47.65
5-Methoxypiperonal, 97%
Buy

Alfa Aesar
L08213
5g$179
5-Methoxypiperonal, 97%
Buy

Alfa Aesar
L08213
25g$590.65
5-Methoxypiperonal, 97%
Buy

TRC
M260955
10g$745
7-Methoxy-1,3-benzodioxole-5-carboxaldehyde
Buy

American Custom Chemicals Corporation
CHM0030883
500MG$796.95
MYRISTICIN ALDEHYDE 95.00%
Buy

**There are several Suppliers, mainly from China **


THIS IS SUCH A FASCINATING VERY VERY VERY VERY VERY HIGH POTENTIAL SEXY MOLECULE

THE BEST DEALS IN TOWN ARE GOING TO BE 5 G FOR $100 ...

MYRISTICIN ALDEHYDE

Y6d5wikN8m

Myristicin
(3-methoxy-4,5-methylenedioxyallylbenzene)
5-methoxy-3,4-methylenedioxy-allylbenzene
Zf3qybMdua

Isomyristicin
1-Methoxy-2,3-methylenedioxy-5-(1-propenyl)benzene
(E)-1-Methoxy-5-propenyl-2,3-(methylenedioxy)benzene
The isomer of myristicin

YKiEdZumsc


Benzaldehyde

Bkerj7Ga08

VIxWbNmOM7



Piperonal
3,4-Methylenedioxybenzaldehyde
1,3-Benzodioxole-5-carbaldehyde
Piperonyl aldehyde

89kFHNdtau



MYRISTICIN ALDEHYDE
5-Methoxypiperonal

3-Methoxy-4,5-(methylenedioxy)benzaldehyde)

7-methoxy-1,3-benzodioxole-5-carbaldehyde


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CAS Number: 5780-07-4
Chemical Formula: C9H8O4
Molecular Weight: 180.16 g/mol

Melting point: 126-132°

Sensitivity: Air Sensitive

Solubility: Insoluble in water.

Notes​

Air Sensitive. Incompatible with air, oxidizing agents. Store under dry inert gas. Store away from air.

1 gram $60

0QAEvkoBNO


MYRISTICIN ALDEHYDE

...

Synthesis of Myristicinaldehyde

"... But from nutmeg oil ?!?! YOU GOT TO BE CRAZY !!! LOL ! ... "

... Suppose SWIM was an eager Beeeee.

This Beeee would UTFSE & experiment with an Essential Oil Distillation of Nutmeg oil (or Mace oil) .
This Beeee read of this weblink https://www.erowid.org/archive/rhodium/chemistry/nutmeg.myristicin.html
"The aromatic ether fraction of oil of nutmeg has been previously shown1 to consist of eugenol (Ia), isoeugenol (IIa), safrole (Ic) and myristicin (Id). Vacuum distillation yields a fraction (bp 109-112°C/1 mmHg; 60g from 1 kg of "W.I." oil of nutmeg (George Lueders and Co.)) which consisted of a substance heretofore accepted both chemically1,2 and pharmacologically3 as the single compound, myristicin (Id)."

According to Alexander S., " (from Oil of Nutmeg) The careful distillation of Oil of Nutmeg (or the Oil of Mace) allowed the isolation of a number of compounds in varying degrees of purity. The fraction that boiled in the 110-115 °C range at about 1.0 mm/Hg was myristicin (3-methoxy-4,5-methylenedioxyallylbenzene). It constituted some 7% of the original oil of commerce and, in its original isolated form, was obtained with a purity of 87%. The major contaminant was elemicin (3,4,5-trimethoxyallylbenzene). "
This Beeee has a theory ~7-12% of a bottle of Nutmeg oil distilled will give the precious MYRISTICIN :).

This Beeeee continued to read "The isomerization of this fraction with alcoholic potassium hydroxide yielded (trans) isomyristicin"
This Beeeee read from another weblink
https://www.erowid.org/archive/rhodium/chemistry/myristicinaldehyde.html
and another weblink https://www.erowid.org/library/books_online/pihkal/pihkal132.shtml
"The syntheses have actually started from myristicinaldehyde (3-methoxy- 4,5-methylenedioxybenzaldehyde) (IV) produced by isomerisation of myristicin to isomyristicin and subsequent oxidation"

This Beeee couldn't find a direct scientific layout of [Isomyristicin ---> Myristicinaldehyde]
...soooo... :/ ... however, SWIM came across a weblink "isosafrole to piperonal" that may be relative ... https://www.erowid.org/archive/rhodium/chemistry/piperonal.isosafrole.html

This Beeeeeee read from this link "

Benzaldehydes from Propenylbenzenes​

by Station

[ Back to the Chemistry Archive ]

Introduction​

The preparation of aromatic aldehydes by the oxidation of compounds with side-chains containing ethylenic linkages via potassium permanganate and potassium dichromate was investigated, including the oxidation of isosafrole to piperonal and of isoeugenol to vanillin.

piperonal.isosafrole.gif

Since the initial materials are not completely miscible with water, the effect of introducing a dispersing agent was studied; for this purpose sulphanilic acid (which had the additional advantage of protecting the aldehyde when formed from further oxidation) and also Dispersol were used. The oxidation of isosafrole to piperonal by potassium permanganate under tested reaction conditions was far too vigorous, and the main product was piperonylic acid, whereas sodium dichromate and sulphuric acid afforded a 70% yield of piperonal, which was increased to 80% and 86.5% by the use of Dispersol and sulphanilic acid respectively as dispersing agents. The higher yield promoted by the sulphanilic acid was ascribed to ephemeral formation of a Schiff's base with the aldehyde when formed. With isoeugenol, in which the benzene structure is not immobilized by the clamping arrangement of the methylenedioxy group, the chromic acid oxidation gives a yield of 67% of vanillin as compared with the 86.5% of piperonal obtained from isosafrole.

Experimental: The preparation of aldehydes​

(a) Without dispersing agent.

A mixture of isosafrole (32.4g, 0.2 mol), 50% aqueous sulphuric acid (160 g) and water (1 L) at 30-40°C was vigorously stirred during the gradual addition over 30 minutes of a solution of sodium dichromate (44g, 0.13 mol, +10% excess) in water (200 ml). Reduction of the dichromate to green chromium salt appeared to be almost immediate; the mixture was twice extracted with benzene (600 ml), and the combined extracts were washed with 5% aqueous sodium hydroxide (200ml) followed by water (500ml). The extract was then dried over anhydrous calcium chloride, and the benzene removed, when the light brown residual oil crystallised on keeping (26g). The crude product was refluxed with ethyl alcohol (200 ml) and animal charcoal (10g), the crude solution filtered hot, and the bulk reduced to 100ml, when the piperonal was obtained in white crystals, mp 36-37°C (yield 21 g of pure product, 70%).

(b) With sulphanilic acid as dispersing agent.

Details were as in (a), except that the isosafrole was added to a solution of sulphanilic acid (12g) and sulphuric acid (80g, d 1.84) in water (1 L). Yield of pure product, 26 g. (86.5%). (c) Details were as in (a) except that Dispersol (5g) was present in the oxidation medium. Yield of pure product 24g (80%).

Experimental--Variations in temperature and in amount of oxidizing agent used:

Variation
Yield
Standard experiment (above)
86.5%​
50% Excess Na2Cr2O7
82.0%​
Theoretical amount Na2Cr2O7
69.0%​
Reaction conducted at 20°C
78.5%​
Reaction conducted at 20°C
73.0%​
"
This Beeeee is sure Isomyristicin ----> Myristicinaldehyde

...

This Beeeee believes this weblink https://www.erowid.org/archive/rhodium/chemistry/myristicinaldehyde.shulgin.html
may be off topic
but [Isomyristicin ------> 1-(3-Methoxy-4,5-methylenedioxyphenyl)-2-nitropropene]
via tetranitromethane


This Beeeee continued reading this discourse " Experimental
1-(3-Methoxy-4,5-methylenedioxyphenyl)-2-nitropropene (2)

A solution of 50 g isomyristicin (1) in 300 ml dry acetone and 24 g pyridine was cooled to 0°C with vigorous stirring. There was then added 54 g of cold tetranitromethane which caused a slight temperature rise (to 5°C) despite the external cooling. The stirring was continued for 2 min at which time the reaction mixture was quenched with a chilled solution of 16.8 g KOH in 300 ml H2O. Stirring was continued while the heat of neutralization dissipated. and the product was then removed by filtration. An additional quantity of the nitropropene (for a total of 50.7 g, 82%) was obtained from the filtrates by extraction with methylene chloride. The low melting point (103°C) was due to a small contamination with myristicinaldehyde which is generated concurrently. Although it cannot interfere with the subsequent reaction below, it can be removed by recrystallization from methanol to yield yellow needles of 2, mp 110°C."

This Beeeee along with the nitropropene discourse, may be simularly conducted with Apiolealdehyde
"
Apiolealdehyde (4, R = OCH3)

Employing the procedure described above for isomyristicin, isoapiole (mp 55–56°C obtained from apiole of Oil of Parsley) was nitrated to 1-(2,5-dimethoxy-3,4 methylenedioxyphenyl)-2-nitropropene, and this intermediate was similarly converted to the aldehyde. This product aldehyde (mp 102–103°C) was obtained in a 75% overall yield from isoapiole."

This Beeeee had ended the off subject discourse and we continue with the
The MYRISTICIN ALDEHYDE.


This Beeeee came into conclusion of this 'aromatic aldehyde' is more rare than of its chemical brother Heliotropin, just guessing there wasn't any aromatherapy fragrance public usage ???
Too much extractions and scientific methods for public corporations to care to spend researching upon this very delicate rare "nutmeg aldehyde"???
Legitimate reason and usage for these special aldehydes ???
Any actual real photo pictures or videos of this aromatic aldehyde ???
What reason of the expensive price ???
What reason of so little scientific notes ???


*********?????????...
MAY SOMEBODY OUT THERE ADD SOME REFERENCES OR SCIENTIFIC LITERATURE
OF
PROPENYLBENZENE OXIDATION VIA potassium permanganate and sodium/potassium dichromate TO ALDEHYDE
...???????????************



??????????? Aromatic allylbenzene ------>
Aromatic aldehyde ????????

Soooo little is known!

This Beeeee believes conducting the propenylbenzene oxidation to the aromatic aldehyde would have more product and save lesssssss $ than to buy those few grams for atleast hundreds of dollars.

Yet Myristicinaldehyde, Piperonal, Apiolealdehyde,
2,4,5-trimethoxy-benzaldehyde (asarone-like),
3,4,5-trimethoxybenzaldehyde (elemicin -like) and more aldehydes have quite a curious fascination, potential for organic chemistry, and are indeed worth a look.

This Beeeee would like to thank the ladies and gentlemen for taking time to read about this interesting science phenomenal.

Thank you



REFERENCES for 3-Methoxy-4,5-methylenedioxybenzaldehyde (Myristicinaldehyde)

Product Link

Myristicin Aldehyde MSDS

5-Methoxypiperonal MSDS

"Nutmeg Benzaldehyde" Chemical & Synthesis Info

A Total Synthesis of Myristicinaldehyde

A Total Synthesis of Myristicin

Benzaldehydes from Propenylbenzenes
Reference: Davies and Hodgson, J.S.C.I., June 1943, 91-93.

Alexander & Ann Shulgin
P.I.H.K.A.L.
#132 MMDA
3-METHOXY-4,5-METHYLENEDIOXYAMPHETAMINE

Alexander & Ann Shulgin
P.I.H.K.A.L.
#109 MDMA
MDM; ADAM; ECSTASY; 3,4-METHYLENEDIOXY-N-METHYLAMPHETAMINE
 

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Chemtrail

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* edit * This Beeeee believes conducting the propenylbenzene oxidation to the aromatic aldehyde would have more product and save moreeeeee$$ than to buy those few grams for atleast hundreds of dollars.
 

The-Hive

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There is several plants that contain Myristicin. nutmeg especially 0.25% to 3.28%
 

Chemtrail

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Another off-topic discourse of an example of a
propenylbenzene isomer ---->
Aromatic nitropropene

P.I.H.K.A.L.

#58 DMMDA​

2,5-DIMETHOXY-3,4-METHYLENEDIOXYAMPHETAMINE


SYNTHESIS: Apiole, as the crystalline essential oil 1-allyl-2,5-dimethoxy-3,4-methylenedioxybenzene, is isolated directly from commercial Oil of Parsley, by careful fractional distillation. It is the fraction that boils at 165-167 °C at 27 mm/Hg. A solution of 19.8 g apiole in a mixture of 43 g KOH and 60 mL hot EtOH was heated in the steam bath for 24 h. With vigorous stirring, it was diluted with H2O, at a rate which the crystals that formed spontaneously could accumulate from the turbidity that was generated. When no more H2O could be added (there was persistent oiling out of material) the reaction mixture was filtered to give 12.1 g of an amber solid material. This was recrystallized from 20 mL boiling hexane, which was filtered while hot to remove insolubles. From the cooled filtrate, there was obtained 9.3 g of 2,5-dimethoxy-3,4-methylenedioxy-1-propenylbenzene, isoapiole, as pale cream-colored solids.

A stirred solution of 8.8 g 2,5-dimethoxy-3,4-methylenedioxy-1-propenylbenzene and 3.9 g pyridine in 45 mL acetone was cooled to ice-bath temperatures, and treated with 7.9 g tetranitromethane. This extremely dark reac-tion was stirred at 0 °C for 5 min, then quenched with a solution of 2.6 g KOH in 45 mL H2O. With continued stirring, there appeared yellow crystals of 1-(2,5-dimethoxy-3,4-methylenedioxyphenyl)-2-nitropropene which, after filtering, washing with 50% acetone and air drying, weighed 8.0 g and had a mp of 110-111 °C.

The same procedure with Oil of Dill :

#59 DMMDA-2
2,3-DIMETHOXY-4,5-METHYLENEDIOXYAMPHETAMINE



[3D .mol structure]
DOSAGE: about 50 mg.

DURATION: unknown.

QUALITATIVE COMMENTS: (with 50 mg) I am into it; it is much like MDA.

EXTENSIONS AND COMMENTARY: This is pretty sparse information upon which to build a picture of biological activity. First, the synthesis was done by someone else and, as I have not been able to find where the notes are, this will be the one recipe in the footnote without explicit directions incorporated.

The procedure used was exactly the same as that described for DMMDA, except that the starting material was dillapiole rather than apiole. The dillapiole was obtained by the careful fractionation of Oil of Dill (as opposed to the isolation of apiole from the careful fractionation of Oil of Parsley). Isomerization to isodillapiole, nitration with tetra-nitromethane to give 1-(2,3-dimethoxy-4,5-methylenedioxyphenyl)-2-nitropropene, and its reduction with LAH in ether to give 2,3-dimethoxy-4,5-methylenedioxyamphetamine hydrochloride (DMMDA-2) proceeded in a precisely analogous manner to the preparation of DMMDA.

There's a Beeee going off-roading with a relative discourse
 

HIGGS BOSSON

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Hello!
MMDA dont have interesting psychoactive effects

A. Shulgin
(with 225 mg) I had a strange awareness of my hands in about 20 minutes--not a feeling in them as just that I was attracted to them somehow. Then I began to get fearful, an acute experience of aloneness. I lay face down (a depressed position for me). Next I was talking to the kids at school (an image) or to other teachers. This was very vivid. The scenes at school were more vivid that the real scenes around me here. Those people were much more real. I am actually very sleepy right now during the experiment. Of any experience I have had, this was most like a series of dreams easily remembered. When it was over, I felt as if I had had a long period of sleeping--I had gone to bed and had a series of dream-like states very vivid and colorful and real.

Phenylethylamines are fairly well studied, and all the best compounds have been described. Of the MDMA analogues, I recommend either Methylone (bk-MDMA) or 4-fluorine amphetamine (4-FA) as the easiest option for obtaining a euphoretic from universally available reagents. Moreover, 4-FA has very interesting effects when taken orally, which can be enhanced by methylation (4-FMA)
 

mycelium

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That sounds groovy, I just read about it...do synthesis exist here???
 

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The synthesis of methylone has been described, and 4-fa is done by analogy with amphetamine
 

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Notes on the isolation of myristicin from parsley seed oil and failures oxidizing isomyristicin to its corresponding aldehyde
from Science madness.com

A good read of dos and donuts




P.s. swim had a difficult time finding a :

A form of "myristicin acid" molecule
Ex. Benzoic acid

A form of "myristicin chloride" molecule
Ex. Benzyl chloride

A form of "myristicin alcohol" molecule
Ex. Benzyl alcohol

.... *Conversion to --> benzaldehyde
*Convert to Aromatic Aldehyde

Is possible


Is possible
Is possible to Convert
piperonyl chloride --->heliotropin
piperonyl alcohol ---> piperonal

Many forms of such "cinnamon -likes'

?! SO WHY NOT sassafras-likes forms
or elemicin-like forms
or myristicin -like forms
or apiole -like forms
or dillapiole -like forms

CONVERSION INTO CORRESPONDING AROMATIC ALDEHYDE ?!

*Swim is NOT talking about the non-aromatic non-phenylpropanoids NOT the leftover animal tissue NOT the "fillers fats" plant fiber *
 

mycelium

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Good morning amieri. Ain't seen ya around for a minute.
I laughed my ass off, as when I was working before I got hurt, and will continue to do, now that I'm better, is check out certain websites during my free time at werk
 

mycelium

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The effects of ground nutmeg in itself, without attempting to extract anything, is very stoning and almost psychedelic,
I consumed it a couple dozen times in prison, and it was older ground spice, not fresh, so that says a lot
Don't know if it was the myristicin or the combination of all of the substances in there(didn't Sasha say there was like 5 substances that would in vivo turn into amphetamines???)
I know that there is website info that says nutmeg oil has a decent amount of safrole, and I was gonna order some but it only has 5%
 

Chemtrail

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Swim found a science based web link of aldehydes , from sciencemadness.com





Aldehyde​

From Sciencemadness Wiki

Stub.png This article is a stub. Please help Sciencemadness Wiki by expanding it, adding pictures, and improving existing text.
An aldehyde or alkanal, is an organic compound containing a functional group with the structure −CHO (or -CH=O), consisting of a carbonyl center (a carbon double-bonded to oxygen) with the carbon atom also bonded to hydrogen, and to an R group, which is any generic alkyl or side chain, or some inorganic group (H, halogen, CF3, etc.).

Contents​

[hide]

Properties​

Aldehydes are volatile compounds, with a strong smell. They are flammable and react with bases, both metal hydroxides and amines, reaction which releases lots of heat. Aldehydes degrade in air via the process of autoxidation, forming various polymers.
Aldehydes polymerize in contact with a strong base, and react exothermically with amines, producing a yellowish insoluble precipitate. Under controlled conditions, it forms the corresponding primary alcohol, and a salt of the corresponding carboxylic acid (Cannizzaro reaction). Aldehydes also react with amines. The reaction of formaldehyde with ammonia for example gives hexamine.
Aldehydes characteristically form "addition compounds" with sodium bisulfite.
Many high weight aldehydes (benzaldehyde, cinnamaldehyde, etc) have strong and pleasant smells.

Preparation​

Aldehydes can be easily prepared through the Jones oxidation of primary alcohols, which consists of chromium trioxide or potassium dichromate dissolved in a mixture of acetone and dilute sulfuric acid.
Chromium-free oxidation routes involve 2-iodoxybenzoic acid (IBX acid), Dess–Martin periodinane, Swern oxidation, TEMPO, or the Oppenauer oxidation.
Aldehydes can also be produced by oxidizing primary alcohols through near red hot copper. This method is simple enough that it can be used to produce large amounts of aldehyde in a lab setting.
Industrially aldehydes are prepared via hydroformylation of alkenes.
Some aldehydes, like benzaldehyde, can be produced by oxidizing toluene with chromyl chloride. Others, like glyoxal are made by oxidizing ethanol or acetaldehyde with nitric acid.
Pyrolysis of calcium formate will yield formaldehyde (dubious):
Ca(HCOO)2 → CH2O + CaCO3
Benzaldehyde and other aromatic aldehydes can be prepared from a benzyl halide and hexamine via the Sommelet reaction.

Safety​

Low weight aldehydes are toxic and carcinogenic. Some may form peroxides upon prolonged contact with air.

References​

Relevant Sciencemadness threads​

 

Chemtrail

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A recipe found in a "Vanillin To MMDA or Mescaline" post

Myristicinaldehyde
58g KF (0.5 mol) was shaken together with a solution of 16.8g (0.1 mol) 5-hydroxyvanillin in 300ml DMF and the solution warmed up a bit. 19.1g (0.11 mol) of methylene bromide (or 9.35g methylene chloride) was added to the cooled solution, and the mixture was heated to 110-120°C for 1.5 hours. The cooled reaction mixture was then separated by ether extraction followed by washing the etheral extracts with water to remove DMF and with cold 10% Na2CO3. Drying and evaporation followed by recrystallization from hexane afforded myristicinaldehyde in high yields (mp 133-134°C).
 

Strike3

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DEA/ DAL CARSON

Talked about 5-Methoxypiperonal
 

Chemtrail

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Names & Synthetic Routes to ecstacy
 

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amieri

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Awesome post ! These maps are really amazing tools to learning.the one in strikes book is what turned on the light for me to have at least a little bit of a understanding
 

Chemtrail

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Thank you, my good man

The sky is the limit here
 

Chemtrail

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A page about Substitute Benzaldehydes
via partial oxidation of substituted propenylbenzenes
 

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amieri

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Is this from ottes book? That's another good one
 

Chemtrail

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A discourse post from myristicin aldehyde...

But these aromatic aldehydes seem promising...

3 4 5 trimethoxybenzaldehyde is not rare -->
TMA

2 4 5 trimethoxybenzaldehyde is slightly rare --->
TMA-2

234 trimethoxybenzaldehyde NOT ACTIVE tma3

2 3 5 trimethoxybenzaldehyde is rare -->
TMA-4

2 3 6 trimethoxybenzaldehyde is rare -->
TMA-5

2 4 6 trimethoxybenzaldehyde is slightly rare --->
TMA-6


**What swim means by "rare' is that swim would search that specific TMBenzaldehyde on a search engine try to find multiple science companies that would sell it
Ex. 5 grams - a $100 or less
25 grams - $100 or two or 3

NOT A FEW MILLIGRAMS FOR HUNDREDS OF DOLLARS !


* P.s. what's the story on those "MDnitropropene" yellow crystals ?! :)

COULDN'T SWIM JUST BY 5-25 GRAMS OF "MDPHENYLNITROPROPENE" AND JUST REDUCE THAT STRAIGHT UP BE REWARDED THE BLESSINGS OF PSYCHEDELIC AMPHETAMINES?! ;)
 

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