One Step Dextroamphetamine Synthesis

[handle]

Kinda sucks when the reagents are more expensive than the end product.
Product: (4S,5R)-(-)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE
Quantity: 5kg
Price: USD $8597.00

 

[Pororo]

Chinese offer it for 500$ per 1 kg. But purity could be questionable.

 

[handle]

Dear, here is our best quotation for you:

1.Product:(4S,5R)-4-Methyl-5-Phenyloxazolidin-2-One, CAS:16251-45-9.

2.Price:USD1739.6/kg including shipping fee, door to door based on 5kg.(Total price is USD8695)

3.Package: 5kg/bag*1 bag, 1 carton

(2layers *0.24mm/layer food grade/pharma grade PET inner bags+1layer*0.24mm/layer

food grade/pharma grade PET Aluminium foil bag+5ply corrugated carton)

4.Delivery: Right away from our warehouse after receiving the payment.

5.Payment: T/T in advance.

6.Validity: 10 working days.

 

[dummy dummietis]

Thank you for an interesting route dear. It looks it can work with Kipp gas generator to run the synth.
I.e., flask is charged with 100 g of (4S,5R)-(-)-4-methyl-5-phenyl-2-oxazolidinone and 5.66 g of Pd/C.
Kipp is charged with 36.37 g of Zn. Acid added and synth goes naturally under standard pressure and RT until all Zn reacted.

Questionable topic is how quickly will the catalyst turns inert and how it is affected by main prec purity?

 

[JassyPinkMan]

Hello. Is it possible to use Raney nickel in the reaction?

 

[Pororo]

I did another attempt to understand this transformation, but all I got as the result of hydration in Pd/C presence is a transformation of oxazolidinone to aminoketone, i.e.:

(4S,5R)-(-)-4-methyl-5-phenyl-2-oxazolidinone+H2 = (1R,2S)-2-amino-1-phenylpropan-1-one

But I totally don't understand HOW it is transformed to amphetamine? Can some one explain this topic, please?

 

[G.Patton]

Hi. Have you carried out this synthesis?

I can't answer you for sure. I assume, that H2 hydrated oxygen atoms and CO2 gas is released as one of the reaction product.

 

[Pororo]

I gonna try it on occasion. But I want to understand the principle first.

If it works precisely as it is said in the document, then I assume, reaction must be stopped periodically to remove CO2. It is not a problem.

The problem is: hydration of oxazolidinone will probably bring us to aminoketone, when O molecule released, then H2O formed and our catalyst is done((((
Or there is something totally different?

 

[madmax777]

Will a video be coming for this procedure