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The synthesis and preliminary pharmacological evaluation of the racemic cis and trans 3-alkylfentanyl analogues
Journal of the Serbian Chemical Society. 69 (7): 511–26. (2004) doi:10.2298/JSC0407511
Great article, lots of useful bits and pieces. Straight from Wikipedia btw.
I want to add a caveat (be careful) regarding F synths in special and drug synths in general as they can be found in scientific articles. Guys, those people are not completely daft if if they are the publishers of the journals are not. You will not find a well working easy synthesis of drugs there even if it looks like it. Those articles (except those where special equipment or reagents are needed) are all booby-trapped with misinformation which is supposed to be obvious to other scientists but not to the person who just wants a recipe for cooking drugs. Well, in reality most of the other scientists don't see those traps but well, thats probably a second purpose.
Some examples:
The Leuckart and making Amphetamine with it is old, so very old but already in 1944 they just left this out or just lied about it really works in special about the hydrolysis step.
All the F synths staring with the piperidone which is reacted to NPP in one way or another, all talking 90% yield and up and everybody who tries it gets some hard resin instead? Thats done on purpose, it is obvious that piperidone if not protected will just react with itself as it has a ketone and an amine group. The only synths they mention with protected piperidone is the benzylated kind which needs Pd/C for deprotection. Also be aware that many Indian articles are just made up stuff to give them a reason to pretend they have a own synthetic pathway to certain drugs as thats whet they need to copy those by Indian patent law.
Super easy Ketamine synths from China. First the Chinese are exaggerating yields like nobody else, for some reason the just MUST do it. And they often publsih upscale methods, whats nice if they were not a little bit missing to really work. As those synths are worth real money in production its more advertisement where they say "we have something great - contact us to make a deal for the real optimized method". Often. Not always.
Ephedrine Biosynth from Sydney University Australia. Those guys even admitted in an interview that they designed their publications and patents in a way nobody without very special knowledge can make ephedrine using those. THey even boasted in an interview how they fooled somebody who contacted them for help in the matter and finally turned him in to the police but not before they made him start and get far enough to cop a really serious sentence. They were actually proud the assholes.
Goes on and on.
Just a reminder.
Journal of the Serbian Chemical Society. 69 (7): 511–26. (2004) doi:10.2298/JSC0407511
Great article, lots of useful bits and pieces. Straight from Wikipedia btw.
I want to add a caveat (be careful) regarding F synths in special and drug synths in general as they can be found in scientific articles. Guys, those people are not completely daft if if they are the publishers of the journals are not. You will not find a well working easy synthesis of drugs there even if it looks like it. Those articles (except those where special equipment or reagents are needed) are all booby-trapped with misinformation which is supposed to be obvious to other scientists but not to the person who just wants a recipe for cooking drugs. Well, in reality most of the other scientists don't see those traps but well, thats probably a second purpose.
Some examples:
The Leuckart and making Amphetamine with it is old, so very old but already in 1944 they just left this out or just lied about it really works in special about the hydrolysis step.
All the F synths staring with the piperidone which is reacted to NPP in one way or another, all talking 90% yield and up and everybody who tries it gets some hard resin instead? Thats done on purpose, it is obvious that piperidone if not protected will just react with itself as it has a ketone and an amine group. The only synths they mention with protected piperidone is the benzylated kind which needs Pd/C for deprotection. Also be aware that many Indian articles are just made up stuff to give them a reason to pretend they have a own synthetic pathway to certain drugs as thats whet they need to copy those by Indian patent law.
Super easy Ketamine synths from China. First the Chinese are exaggerating yields like nobody else, for some reason the just MUST do it. And they often publsih upscale methods, whats nice if they were not a little bit missing to really work. As those synths are worth real money in production its more advertisement where they say "we have something great - contact us to make a deal for the real optimized method". Often. Not always.
Ephedrine Biosynth from Sydney University Australia. Those guys even admitted in an interview that they designed their publications and patents in a way nobody without very special knowledge can make ephedrine using those. THey even boasted in an interview how they fooled somebody who contacted them for help in the matter and finally turned him in to the police but not before they made him start and get far enough to cop a really serious sentence. They were actually proud the assholes.
Goes on and on.
Just a reminder.