Methamphetamine Isomers Separation by Tartaric Acid

Mr Good Cat

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@G.Patton general, is it not more simple to use d-tartaric acid CAS No. 147-71-7 but in much more less molar proportions around 1 (base):0.2-0.5 (d-tartaric)? Exact proportions might be estimated with a simple test.
 

G.Patton

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Yes, you can use d-tartaric acid CAS No. 147-71-7, but it's more expensive and some people don't have an access to this. The example is shown with the cheapest and the simplest option.
 
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Bmth

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True to that it does not produce crystals, can you help there to be the correct tartarat, or maybe the formula of the substance 🙏
 

Bmth

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Bis Can you give me instructions about the procedure, or a link to the procedure? Thank you very much. 🙏
 

Bmth

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HLlku3fb2X

Atau y Or is this one? Please help these experts have tried the 4th time I got a failure. 🤣🤣
 
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G.Patton

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There is clearly said what substance you have to use. What a problem do you have?
 

OrgUnikum

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The main problem with this method is that one gets l-Meth, to be more precise one gets from slightly enriched l-Meth to predominantly l-Meth depending on how long one lets it crystallize out. The more time the more l-Meth is in the cristalline mass. When good stirring is employed the result will be even more l-meth in the crystals (in relation of course).
The good thing s that one gets pretty decent d-Meth fromm the mother liquor.

It does not matter if one uses l-tartaric or d-tartaric or d/l tartaric - it will always be l-Meth what crystallizes out most. It is completely different from Amphetamine btw. cannot be compared at all. I actually understood what is really going on only a short time ago and I fully understand why somebody might believe I am wrong, but well, I am not.

As I try not to criticize when I cannot offer an alternative, here it is:
7.84 g (0.0525 mol) racemic N-methylamphetamine and 9.73 g (0.0525 mol) racemic N-methylamphetamine hydrochloride were dissolved in 70 ml of abs. ethanol and 7.91 g (0.0525 mol) R,R tartaric acid (L-(+)-tartaric acid) in 56 ml of abs. ethanol.
Strong stirring for twenty two hours. room temperature, then the mixture is cooled in the fridge, the formed salt is filtered out and the mother liquor is worked up by A/B extraction and recrystallisation to yield almost exclusively d-Meth.

Its all in the literature. Just not in one place but a bit obfusicated.

Good luck
 
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