The video is not working anymore or it is in private, please help i want to watch it??
LSD synthesis video
- Thread starter psy
- Start date
Just watched it and it has been quite a revelation to see the process which is nice of them to show in full light nonetheless still offended to some extent by the redundancy of the information and the common language which in my personal opinion should be kept academic. We'll see if it works just as stated soon enough.
- By mycelium
Herr Haber, I don't know about the dude until I watched a couple of his videos, but like most 'influencers' he is just telling you what someone else does, not himself
There are too many inconsistencies in his story to think he knows what he is doing.
1) it is not Hoffman's formula, Hofmann used azide in his formula(it's in a patent, go read it) this tek uses POCl3.
2) D-LAME didn't exist in Hoffman's time, nor in Sasha's time. It's a new invention.
3) this is shulgins formula, from #26 in TiHKAL. With D-LAME replacing D-LA
4) he stops the video after allegedly obtaining LSD freebase, which is not stable, and says this is liquid acid, which it's not, and it doesn't look like LSD base, he doesn't make a salt (tartrate or maleate) etc.
5) I thought it was in TiHKAL but it wasn't...somewhere I read that the diethylamine and the POCl3 need to be put in at the same time, from different neck-of-the-flask, drop wise...not mixed together like they're making a drink..
Either way, while I believe the base hydrolysis to convert the D-LAME to D-LA is correct, based on shit I've read, I do not believe that kid EVER made acid, or knew the chemists, or even knows a lot about chemistry.
I am not a chemist. I did know an LSD chemist, I talked to him in 2 different states 3400 miles apart, in person. The first time he told me how to make ugly acid pretty and I didn't even know what norit was, didn't know here was methanol, and didn't know what recytalization was...The second time he sold me super cheap MDMA at RFK'93
Yet I digress...here is shulgins TiHKAL entry for L
**********************************
A suspension of 3.15 g d-lysergic acid hydrate and 7.1 g of diethylamine in 150 mL CHCl3 was brought to reflux with stirring. With the external heating removed, there was added 3.4 g POCl3 over the course of 2 min, at a rate sufficient to maintain refluxing conditions. The mixture was held at reflux for an additional 5 min, at which point everything had gone into solution. After returning to room temperature, the solution was added to 200 mL of 1 N NH4OH. The phases were separated, the organic phase dried over anhydrous MgSO4, filtered, and the solvent removed under vacuum. The residue was chromatographed over alumina with elution employing a 3:1 C6H6/CHCl3 mixture, and the collected fraction stripped of solvent under hard vacuum to a constant weight. This free-base solid can be recrystallized from benzene to give white crystals with a melting point of 87-92 °C. IR (in cm-1): 750, 776, 850, 937 and 996, with the carbonyl at 1631. The mass spectrum of the free base has a strong parent peak at mass 323, with sizable fragments at masses of 181, 196, 207 and 221.
This base was dissolved in warm, dry MeOH, using 4 mL per g of product. There was then added dry d-tartaric acid (0.232 g per g of LSD base), and the clear warm solution treated with Et2O dropwise until the cloudiness did not dispel on continued stirring. This opaqueness set to a fine crystalline suspension (this is achieved more quickly with seeding) and the solution allowed to crystallize overnight in the refrigerator. Ambient light should be severely restricted during these procedures. The product was removed by filtration, washed sparingly with cold methanol, with a cold 1:1 MeOH/Et2O mixture, and then dried to constant weight. The white crystalline product was lysergic acid diethylamide tartrate with two molecules of methanol of crystallization, with a mp of about 200 °C with decomposition, and weighed 3.11 g (66%). Repeated recrystallizations from methanol produced a product that became progressively less soluble, and eventually virtually insoluble, as the purity increased. A totally pure salt, when dry and when shaken in the dark, will emit small flashes of white light.
There are too many inconsistencies in his story to think he knows what he is doing.
1) it is not Hoffman's formula, Hofmann used azide in his formula(it's in a patent, go read it) this tek uses POCl3.
2) D-LAME didn't exist in Hoffman's time, nor in Sasha's time. It's a new invention.
3) this is shulgins formula, from #26 in TiHKAL. With D-LAME replacing D-LA
4) he stops the video after allegedly obtaining LSD freebase, which is not stable, and says this is liquid acid, which it's not, and it doesn't look like LSD base, he doesn't make a salt (tartrate or maleate) etc.
5) I thought it was in TiHKAL but it wasn't...somewhere I read that the diethylamine and the POCl3 need to be put in at the same time, from different neck-of-the-flask, drop wise...not mixed together like they're making a drink..
Either way, while I believe the base hydrolysis to convert the D-LAME to D-LA is correct, based on shit I've read, I do not believe that kid EVER made acid, or knew the chemists, or even knows a lot about chemistry.
I am not a chemist. I did know an LSD chemist, I talked to him in 2 different states 3400 miles apart, in person. The first time he told me how to make ugly acid pretty and I didn't even know what norit was, didn't know here was methanol, and didn't know what recytalization was...The second time he sold me super cheap MDMA at RFK'93
Yet I digress...here is shulgins TiHKAL entry for L
**********************************
A suspension of 3.15 g d-lysergic acid hydrate and 7.1 g of diethylamine in 150 mL CHCl3 was brought to reflux with stirring. With the external heating removed, there was added 3.4 g POCl3 over the course of 2 min, at a rate sufficient to maintain refluxing conditions. The mixture was held at reflux for an additional 5 min, at which point everything had gone into solution. After returning to room temperature, the solution was added to 200 mL of 1 N NH4OH. The phases were separated, the organic phase dried over anhydrous MgSO4, filtered, and the solvent removed under vacuum. The residue was chromatographed over alumina with elution employing a 3:1 C6H6/CHCl3 mixture, and the collected fraction stripped of solvent under hard vacuum to a constant weight. This free-base solid can be recrystallized from benzene to give white crystals with a melting point of 87-92 °C. IR (in cm-1): 750, 776, 850, 937 and 996, with the carbonyl at 1631. The mass spectrum of the free base has a strong parent peak at mass 323, with sizable fragments at masses of 181, 196, 207 and 221.
This base was dissolved in warm, dry MeOH, using 4 mL per g of product. There was then added dry d-tartaric acid (0.232 g per g of LSD base), and the clear warm solution treated with Et2O dropwise until the cloudiness did not dispel on continued stirring. This opaqueness set to a fine crystalline suspension (this is achieved more quickly with seeding) and the solution allowed to crystallize overnight in the refrigerator. Ambient light should be severely restricted during these procedures. The product was removed by filtration, washed sparingly with cold methanol, with a cold 1:1 MeOH/Et2O mixture, and then dried to constant weight. The white crystalline product was lysergic acid diethylamide tartrate with two molecules of methanol of crystallization, with a mp of about 200 °C with decomposition, and weighed 3.11 g (66%). Repeated recrystallizations from methanol produced a product that became progressively less soluble, and eventually virtually insoluble, as the purity increased. A totally pure salt, when dry and when shaken in the dark, will emit small flashes of white light.
- By mycelium
Here is shulgin explaining the coupling methods and when they were used...
The amide lysergamide, a component of several varieties of morning glory seed, is also a controlled drug and, by law, a depressant. The earliest syntheses of LSD involved the used of an azide intermediate (the original Hofmann process, 1955), mixed anhydrides with trifluoroacetic anhydride (1956) or sulfuric anhydride (SO3-DMF on the lithium salt, 1959), with the peptide condensation agent N,N'-carbonyldiimidazole (1960), or with the acid chloride as the active intermediate with POCl3, PCl5 or thionyl chloride (1963) or just phosphorus oxychloride (1973). Most methods are faulted due to excessive moisture sensitivity, generation of side-products, or epimerization or inversion at the 8-position carbon to form d-iso-LSD. The POCl3 procedure is clean and fast, and is the preferred process today for the synthesis of a wide variety of substituted lysergamides.
The amide lysergamide, a component of several varieties of morning glory seed, is also a controlled drug and, by law, a depressant. The earliest syntheses of LSD involved the used of an azide intermediate (the original Hofmann process, 1955), mixed anhydrides with trifluoroacetic anhydride (1956) or sulfuric anhydride (SO3-DMF on the lithium salt, 1959), with the peptide condensation agent N,N'-carbonyldiimidazole (1960), or with the acid chloride as the active intermediate with POCl3, PCl5 or thionyl chloride (1963) or just phosphorus oxychloride (1973). Most methods are faulted due to excessive moisture sensitivity, generation of side-products, or epimerization or inversion at the 8-position carbon to form d-iso-LSD. The POCl3 procedure is clean and fast, and is the preferred process today for the synthesis of a wide variety of substituted lysergamides.