Alpha-PVP synthesis (1-10kg scale). Complete video tutorial.

[VamonosPest]

What could i replace pyrrolidine with?

 

[Hank Schrader]

Methylamine. You will get also good product.

 

[a.hatam]

Hi
how many grams?

 

[Caleb]

Of course that's not true. Precursors may be considered legal in some parts of the EU, but they are those regions in the middle of EU where you get 9 years jail for only ordering those "legal" chemicals.
Don't worry if you need some action, they will storm your home and throw you on the floor and handcuff you. Actually they do this for much lesser felony like carrying a grinder.

 

[Caleb]

Of course there is no arguing in: "Chemical1 is not listed as illegal." The fact only that it can be used to produce an illegal drug is easily enough to get a full sentence. The good site about it is: When the people catch you, you will have a much worse fate.
I hear in other parts of the world, like Texas, there is about the same. Therefore this neglect here is not understandable.

 

[Polka999]

Hello. Can i replace Anhydrous Acetone with just Acetone? or maybe something else.

 

[HIGGS BOSSON]

It is better to use acetone. If you have "just" acetone, then it can be drained.

 

[rado]

Which solvent for Alpha-PVP synthesis is better to use instead of ethyl acetate, so that it can be acidified in excess of water and the solvent does not mix with an aqueous base

 

[WillD]

benzene homologues

 

[Cranston]

So.. Until now my question remains unanswered what are the typical remaining toxic chemicals in the alpha* synthesises. Some batches can really cause havoc in the lungs and for health safety this information is very important.

@William Dampier, @G.Patton, @HIGGS BOSSON, you are so great chemists. You surely have answers!

 

[G.Patton]

Hello. If you follow our video tutorial, you won't get any toxic substances in your product.

 

[Cranston]

Actually I haven't made anything yet. Talking about the products made by others.

I thought that you chemical experts knew possible impurities and can tell. But I heard that not everybody knows that Potassium Permanganat is used by Chinese labs when they producing substances for us.

 

[G.Patton]

Can you describe your thought and logic concerned potassium permanganate and its dependence between final products impurities?

 

[Cranston]

So, I am trying to anwer the questions myself: My guess is, that Pyrrolodine as the main impurity that causes breathing problems.
It's not only obvious because it used in the synthesis, it's boiling point is very close to those of the pyros, which could explain that it comes so quick into the lungs.

But one thing I do NOT understand: It should be washed away very well with anhydrous cold acetone. So how it is possible that it is still in some products?

 

[G.Patton]

A pyrrolidine excess will be distilled off with ethyl acetate. Moreover it has liquid state at normal condition and can be easy determined. If you see liquid a-PVP, don't use it and wash/dry.
I can tell you that I've never seen such a-PVP, although I have seen a lot of samples.

 

[Caleb]

so what are those impurities? a friend of my fanboy acetone-washed some a-pvp from a vendor of this site. it was full of yelloe sh*t, sorry those words. what are those?
why don't you check quality and health hazards here?

 

[viking1111]

Hello, in what is the best recrystalize powder i tried to put 1:1 with aceton and to freezer but its still comming powder

 

[Aggro38]

Beautiful scheme, seeing how much each reagent or substrate contributes to the process is astounding even after many reactions. I used molecular sieves in chilled Acetone to help it stay dry before addition as well as chilling the FB, and had precipitation of up to and over 95% yield of racemic fairly frequently.

 

[efanefan]

Hello, I'd like to ask if I can use phenhexanone to make alpha-PHP? Also use hydrogen peroxide and hydrobromic acid for bromination, and pyrrolidine deamination? Thank you very much

 

[badboy345]

u need use hcl 30% 37%

 

[dr_strangelove]

A rotary evaporator is in the equipment list? But skimming the instructions and the videos, I didn't notice one being used. Am I missing something? Or is it something that is 100% NOT needed for this? Hopefully it's the latter. Because the cheapest one ive seen is 2x the cost of the rest of the equipment list combined

 

[dr_strangelove]

Would a heating plate with a magnetic stirrer work? Or is there a specific reason that an overhead stirrer should be used? I'm by no means anything close to a chemist. So please forgive me if any of my questions are foolish ones