Sinteze 2C-fenilentilaminov

[NarwhalFucker419]

Ali ima kdo informacije o bromiranju 2C-H z n-bromosukcinimidom? Videl sem, da je nekaj ljudi to omenilo drugje, vendar nisem našel nobenega opisa.

 

[Raxmil]

Tudi to iščem, vendar nisem našel podrobnih informacij
Vem le, da lahko to naredite v GAA ali DCM, vendar nimam pojma o razmerju

 

[amieri]

There's a person in maybe theehive on Reddit.i believe the also have a mescaline synth posted too and a few others.

 

[btcboss2022]

Imam dvom glede zadnjega koraka sinteze 2CB. Piše: "Reakcijska zmes se je vrnila na sobno temperaturo, filtrirala in trdne delce previdno izpirala s hladno ocetno kislino." Dokler ne vem, da ocetna kislina postane trdna pri 16-17C, kaj točno pomeni hladna ocetna kislina?
Hvala.

 

[G.Patton]

Pozdravljeni. predvidevam, da hladna kislina pomeni sobno temperaturo, saj je razlaga, da se pri reakciji sprošča toplota.

 

[btcboss2022]

Okej, okej, tudi jaz sem tako mislil, vendar sem raje potrdil, saj veste, ko rečemo hladno, običajno mislimo iz zamrzovalnika in ne RT hahaha, vendar pri ocetni kislini to ni mogoče ;-) hvala

 

[w2x3f5]

Ne razumem čisto dobro, zakaj pralni amin hidrobromid, ni ga mogoče uporabiti, saj se zažge. Bolje je očistiti in dobiti hidroklorid in izgube so manjše, saj se tako izognemo dvomljivim poskusom pranja prahu iz broma.

 

[nujrc]

Razumem, da bo preostali elementarni brom iz proizvoda izhlapeval v zraku, tako kot vsako topilo, zato sčasoma ne bo ostala nobena razumna količina. Izdelava HCL brez sušenja HBr - veliko sreče, da boste dobili čistejši izdelek, saj boste morda imeli opravka z bromovimi solmi v raztopini brom/GAA in samim bromom.

 

[w2x3f5]

Ne vidim nobenih težav, da ostanke broma zbij o s tiosulfatom , nato ph privedej o do alkalnega sredst va in olje zberej o s topilom .

 

[situ1984]

(R)-(+)-α-metilbenzilamin Številka CAS: (R)-(+)-α-metilbenzilamin:
3886-69-9 Ali je iz pljuč? Ali se absorbira iz želodca? Ali se lahko uporablja neposredno?
(R)-(+)-α-metilbenzilamin Številka CAS: 38866-1:
3886-69-9 Ali je iz pljuč? Ali se absorbira v želodcu? Ali se lahko uporablja neposredno?

 

[G.Patton]

Nima psiholoških učinkov.

 

[amieri]

Kje dobimo 2,5 dimetinitrostiren

 

[HerrHaber]

Henryjeva kondenzacija 2,5-dimetoksibenzaldehida z nitrometanom v prisotnosti primarnega amina kot katalizatorja.

 

[amieri]

It blows my mind how far I've come in this since I wrote this . You guys are all works of inspiration thanks for sharing

 

[taricshop]

ali je mogoče pri sintezi 2cb elementarni brom nadomestiti s hbr kislino?
@G.Patton

 

[Newbee]

@HEISENBERG @WillD @G.Patton
Question to you guys.Is it possible to perform bromination of 2ch to 2cb by NBS (N-Bromosuccinimide)
instead of elemental bromine (br2)

 

[G.Patton]

Hello.
Yes, I think so.

 

[amieri]

That's seems to be the new go to I see alot.i need to get some succinimide acid n give it a try.

 

[Newbee]

i found some writeups on thehivee but im not sure about it i also cant try do it on my own. but NBS seems to be safer to use than BR

 

[amieri]

I use a 2×2×4 grow tent in its side with a 8" inline fan going out the building as a hood up on a folding table definitely does the job,still wear a mask non the less. Make sure you have a 5% sodium thiosulphate solution on hand in case of a accident and a rubber made bin with enough of that solution to run through you glass at the end.and think every step out. You got this my friend can't wait to hear of your success.

 

[Swirly]

Yes, you can brominate with NBS on 2c-h HCl, you can read in my post.
You could even risk NBS bromination on 2c-h freebase in DCM or on the oxalate/sulfate salts.

Have a read:

https://bbgate.com/en-gb/threads/a-mostly-kitchen-friendly-synthesis-of-2c-b.13198/#post-73488

 

[amieri]

Sure you can, obviously dig as deep as you can researching hand but the fact you came this far says a lot.so keep pushing and if you waste something you at least gain the experience.now safety if thats what your concerned about thats a horse of a different color

 

[Rabidreject]

I just wanted to say thanks for this incredibly involved set of syntheses.
It is really impressive.
It’s funny, I made quite a few different nitrostyrene’s and nitropropene’s and then when I started reducing them and getting decent yields on active molecule’s, I started thinking okay, well it can’t be that much harder to produce the 2c-x compounds, then you see people making 2c-b and presumably other haloginated 2c’s and you think ah okay.

Then you start digging into the alkylated 2c compounds and my oh my does the chemistry take a jump in complexity!!

Anyway, I’m pretty convinced that my next major project is going to have to be the ethylated 4 position.
Is that a friedl-crafts alkylation you do to the 2,5-dimethoxyacetophenone, I mean in order to get from that to the 2,5-dimethoxy-1-ethylbenzene?

I think the most annoying part of it is that I’m going to have to get a vacuum pump that runs to super high vacuum!

Anyway, be prepared to be bugged by me a lot in the coming months/years because once I set my mind to something, I WILL learn how to get it done. It often involves harassing old posters! Ha