Syntézy 2C-fenyletylamínov

[NarwhalFucker419]

Má niekto informácie o bromovaní 2C-H pomocou n-brómosukcinimidu? Videl som, že to niekoľko ľudí spomína inde, ale nenašiel som žiadne písomné informácie.

 

[Raxmil]

Aj ja to hľadám, ale nepodarilo sa mi nájsť podrobné informácie
Viem len, že to môžete robiť v GAA alebo DCM, ale nemám predstavu o pomere

 

[amieri]

There's a person in maybe theehive on Reddit.i believe the also have a mescaline synth posted too and a few others.

 

[btcboss2022]

Mám pochybnosti nad posledným krokom syntézy 2CB. Píše sa tam: "Reakčná zmes sa nechala vrátiť na izbovú teplotu, prefiltrovala sa a tuhé látky sa šetrne premyli studenou kyselinou octovou." Pokiaľ viem, kyselina octová sa stáva tuhou pri teplote 16-17 C, tak čo presne znamená studená kyselina octová?
Ďakujem.

 

[G.Patton]

Ahoj. predpokladám, že studená kyselina znamená izbovú teplotu, pretože je tam vysvetlenie, že pri reakcii sa uvoľňuje teplo.

 

[btcboss2022]

Ok ok, aj ja som si to myslel, ale radšej som si to potvrdil, ako viete, keď hovoríme studený, normálne tým myslíme z mrazničky, nie RT hahaha, ale pri kyseline octovej to nie je možné ;-) vďaka

 

[w2x3f5]

Celkom nerozumiem, prečo sa umýva aminhydrobromid, nedá sa to použiť, horí to. Lepšie je čistiť a získať hydrochlorid a straty sú menšie, ako sa vyhnúť pochybným pokusom o pranie prášku z brómu.

 

[nujrc]

Chápem, že zostávajúci elementárny bróm sa z výrobku vyparí do vzduchu, rovnako ako každé rozpúšťadlo, takže časom nezostane žiadne primerané množstvo. Výroba HCL bez sušenia HBr - veľa šťastia, aby ste získali čistejší produkt, pretože sa možno budete musieť vysporiadať so soľami brómu v roztoku brómu/GAA a so samotným brómom.

 

[w2x3f5]

Nevidím žiadny problém vytĺcť zvyšky brómu tiosíranom, potom priviesť ph do alkalického prostredia a olej zachytiť rozpúšťadlom.

 

[situ1984]

(R)-(+)-α-metylbenzylamín Číslo CAS:
3886-69-9 Je z pľúc? Alebo sa vstrebáva zo žalúdka? Môže sa použiť priamo?
(R)-(+)-α-metylbenzylamín Číslo CAS:
3886-69-9 Pochádza z pľúc? Alebo sa absorbuje žalúdkom? Môže sa použiť priamo?

 

[G.Patton]

Nemá žiadne psychologické účinky.

 

[amieri]

Kde sa dá získať 2,5 dimetynitrostyrén

 

[HerrHaber]

Henryho kondenzácia 2,5-dimetoxybenzaldehydu s nitrometánom v prítomnosti primárneho amínu ako katalyzátora.

 

[amieri]

It blows my mind how far I've come in this since I wrote this . You guys are all works of inspiration thanks for sharing

 

[taricshop]

Je možné nahradiť elementárny bróm kyselinou hbr pri syntéze 2cb?
@G.Patton

 

[Newbee]

@HEISENBERG @WillD @G.Patton
Question to you guys.Is it possible to perform bromination of 2ch to 2cb by NBS (N-Bromosuccinimide)
instead of elemental bromine (br2)

 

[G.Patton]

Hello.
Yes, I think so.

 

[amieri]

That's seems to be the new go to I see alot.i need to get some succinimide acid n give it a try.

 

[Newbee]

i found some writeups on thehivee but im not sure about it i also cant try do it on my own. but NBS seems to be safer to use than BR

 

[amieri]

I use a 2×2×4 grow tent in its side with a 8" inline fan going out the building as a hood up on a folding table definitely does the job,still wear a mask non the less. Make sure you have a 5% sodium thiosulphate solution on hand in case of a accident and a rubber made bin with enough of that solution to run through you glass at the end.and think every step out. You got this my friend can't wait to hear of your success.

 

[Swirly]

Yes, you can brominate with NBS on 2c-h HCl, you can read in my post.
You could even risk NBS bromination on 2c-h freebase in DCM or on the oxalate/sulfate salts.

Have a read:

https://bbgate.com/en-gb/threads/a-mostly-kitchen-friendly-synthesis-of-2c-b.13198/#post-73488

 

[amieri]

Sure you can, obviously dig as deep as you can researching hand but the fact you came this far says a lot.so keep pushing and if you waste something you at least gain the experience.now safety if thats what your concerned about thats a horse of a different color

 

[Rabidreject]

I just wanted to say thanks for this incredibly involved set of syntheses.
It is really impressive.
It’s funny, I made quite a few different nitrostyrene’s and nitropropene’s and then when I started reducing them and getting decent yields on active molecule’s, I started thinking okay, well it can’t be that much harder to produce the 2c-x compounds, then you see people making 2c-b and presumably other haloginated 2c’s and you think ah okay.

Then you start digging into the alkylated 2c compounds and my oh my does the chemistry take a jump in complexity!!

Anyway, I’m pretty convinced that my next major project is going to have to be the ethylated 4 position.
Is that a friedl-crafts alkylation you do to the 2,5-dimethoxyacetophenone, I mean in order to get from that to the 2,5-dimethoxy-1-ethylbenzene?

I think the most annoying part of it is that I’m going to have to get a vacuum pump that runs to super high vacuum!

Anyway, be prepared to be bugged by me a lot in the coming months/years because once I set my mind to something, I WILL learn how to get it done. It often involves harassing old posters! Ha