Hello everyone. I tried to make some amphetamine using this recipe on a small scale, but failed. Everything seemed ok, after drying my product looked like white powder with a tinge of redness. If it was amphetamine sulfate (which I was trying to make), the yield would be 84%. The problem is, it's not amphetamine.
Physiological effects
I tried 20-30 mg, there was definitely stimulation, but also it caused fever and, apparently, a decline in immunity: both times I took it for several days in a row, I fell ill with respiratory infections (first time I thought it was a coincidence). Another person that took it did not experience any stimulation from up to 90 mg, only some mouth dryness. Neither of us have any tolerance to stimulants.
Chemical testing
1 g of the powder completely dissolves in 10 ml H2O.
When I added excess NaOH solution to a measured mass of the powder in a test tube, I got an approximately right volume of freebase smelling of ammonia. I separated the freebase layer, dried it with CaCl2 and tried to titrate it with acid. As a result, I measured molar mass of the freebase to be about 171 (and for amphetamine it's 135). While my measurements weren't very precise, the difference is still too large to be explained by measurement errors alone.
My deviations from the procedure
1) When adding P2NP, I realized it was going to take hours, so I got impatient and immersed the reaction flask in a room temperature water bath. After that I was able to add P2NP almost all at once, and the temperature of the mixture didn't exceed 40-50 °С.
2) I was following the video, so I didn't evaporate the IPA and added conc. sulfuric acid to the IPA/freebase layer directly.
3) I didn't have any acetone at the moment, so I didn't add it before acidifying and I washed the filtered "amphetamine sulfate" paste with IPA.
4) IPA is less volatile than acetone, so I had to put my precipitate in an oven for several hours to dry it to constant weight. The temperature in the oven didn't exceed 80 °С.
So, the big question is, where did it go wrong? I wouldn't be surprised with low yield or no product at all, but getting a good yield of an amine that's not amphetamine?!
Physiological effects
I tried 20-30 mg, there was definitely stimulation, but also it caused fever and, apparently, a decline in immunity: both times I took it for several days in a row, I fell ill with respiratory infections (first time I thought it was a coincidence). Another person that took it did not experience any stimulation from up to 90 mg, only some mouth dryness. Neither of us have any tolerance to stimulants.
Chemical testing
1 g of the powder completely dissolves in 10 ml H2O.
When I added excess NaOH solution to a measured mass of the powder in a test tube, I got an approximately right volume of freebase smelling of ammonia. I separated the freebase layer, dried it with CaCl2 and tried to titrate it with acid. As a result, I measured molar mass of the freebase to be about 171 (and for amphetamine it's 135). While my measurements weren't very precise, the difference is still too large to be explained by measurement errors alone.
My deviations from the procedure
1) When adding P2NP, I realized it was going to take hours, so I got impatient and immersed the reaction flask in a room temperature water bath. After that I was able to add P2NP almost all at once, and the temperature of the mixture didn't exceed 40-50 °С.
2) I was following the video, so I didn't evaporate the IPA and added conc. sulfuric acid to the IPA/freebase layer directly.
3) I didn't have any acetone at the moment, so I didn't add it before acidifying and I washed the filtered "amphetamine sulfate" paste with IPA.
4) IPA is less volatile than acetone, so I had to put my precipitate in an oven for several hours to dry it to constant weight. The temperature in the oven didn't exceed 80 °С.
So, the big question is, where did it go wrong? I wouldn't be surprised with low yield or no product at all, but getting a good yield of an amine that's not amphetamine?!
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- By OrgUnikum
The method as described here lacks all product workup/cleanup and and as such provides a very dirty and unclean Amphetamine, in special as NasBH4 reductions are all not giving very clean product. Purple MDMA and such.
I know the physiological effects like fever like very well and it is just the missing cleaning trust me.
There are several ways to do the workup, from distillation, normal, vacuum or steam of the base or dissolving the sulfate in water and washing this several times with toluene or petrolether or my favorite: 50/50 mix of petrol ether and Ethylacetate. Then evaporate the water and wash the resulting salt with copious amounts of Acetone and petrol ether as last. Already the simple washings give you a consumable product which does not make you sick like the crap which contains borate salts or else.
I know the physiological effects like fever like very well and it is just the missing cleaning trust me.
There are several ways to do the workup, from distillation, normal, vacuum or steam of the base or dissolving the sulfate in water and washing this several times with toluene or petrolether or my favorite: 50/50 mix of petrol ether and Ethylacetate. Then evaporate the water and wash the resulting salt with copious amounts of Acetone and petrol ether as last. Already the simple washings give you a consumable product which does not make you sick like the crap which contains borate salts or else.
- By waltjr5858
Even with the dirtiest amp he would have felt it just fine....guaranteed he got "almost amp" mainly riddled with hydroxylamine. This reaction goes south on people all the time. They have wayyyy too much nabh4 left when it's time to add the copper and with the heat the nanoparticles aggregate and become completely useless as a catalyst....fully useless... and leave semi reduced product. The only way I've been able to get around that is by reducing 1st in methanol/thf to propane then extracting and then using anyone of the zinc/formic acid combos.... for the nitro. Zero Michael addition.