4'-metilpropiofenona sintēze no toluola, izmantojot Frīdela-Kraftsa reakciju (1 kg+ mērogā)

[Deedubbau]

Drošības kungs glābšanai....

Jā, labāk pārliecinieties, ka valkā visus aizsargaprīkojumus. Jo, ja jūs ņemsiet vērā šo padomu un izmantosiet nerūsējošo tēraudu, jūs piedzīvosiet katastrofu. Nerūsējošajam tēraudam strauji uzbrūk organiskās skābes un hlorīdi. Tāpēc, kad jūs uzsildīsiet šo maisījumu, labāk esiet gatavs palaist....vai vienkārši izmantojiet stiklu.

 

[amieri]

"let me show you something"

 

[NovicechemistEU]

Tomorrow I'm starting the big day synthesis with a small batch.
I wanted to start with a small batch for my first try.
1.08 mol 100 Gr 95.2 mL propionyl chloride
1.12 mol 150 Gr: AlCl₃
2.81 mol 300 ml 261 Gr Toluene
I can use 50 ml more toluene. 350 ml
Toluene of 99.5% purity was dried and then distilled under vacuum. We follow the advice of the masters

 

[William D.]

Do not forget to pour it into cold water. Not water into the reaction mixture. This is very important.

 

[Smokesalot99]

Can you replace propionyl chloride with propionic anhydride for reaction?

 

[The-Hive]

try it and let us no do it on a small scale then compare it to using propionyl chloride

 

[William D.]

Do you think this reagent is more easy to buy? And cheaper? I think this is not so, but if you have it, you can go with such a route but with correction.

 

[NovicechemistEU]

I finally managed to make the synthesis, I can't thank @William D. enough for helping me every step of the way, I am very grateful
Now I just need to distill the dirty 4'-methylpropiophenone under vacuum