JWH-018 sintēze

William D.

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Video nav, bet varu detalizēti konsultēt par procesu šeit, privātā vēstulē vai XMPP. Man ir pietiekama praktiskā pieredze šajā sintēzē.
 
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William D.

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Ja produkts nekristalizējas no spirta, var ieliet aukstu ūdeni un iegūt nogulsnes. Nepieciešamais 018 daudzums zālēm ir atkarīgs no iegūtās kvalitātes un jūsu tolerances. Pētījumos dokumentētā deva - 2 mg uz vienu trāpījumu. Bet es domāju, ka vairāk.
 

Eagle1234

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Liels paldies par atbildi. Tā bija ļoti noderīga informācija. Es to novērtēju.
Vai ir normāli, ka 3(1-naftoil)indola krāsa kļūst sarkana, kad to mazgā ar ūdeni?
 

Yunik777

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Sveiki, mans draugs, es neesmu ļoti labs ķīmiķis, bet man izdevās izgatavot jwh un 5f no prekursoriem, ko es iegādājos ārzemēs, un man bija jautājums, jo es studēju kanabinoīdu ķīmiju, vai būtu iespējams konstruēt kanabinoīdus no naftalēna (naftalīna)
Tāpat es saprotu, ka karboksilātiem un sintētiskajiem piretroīdiem ir ļoti interesantas īpašības, ko var izmantot kanabinoīdu radīšanai? Vai jums būtu kas sakāms par to vai arī varētu man kaut kā palīdzēt? Es uzzināju, ka cipermetrīns pastiprina kanabinoīdu iedarbību.... tas ir loģiski, jo piretroīdi iedarbojas uz nervu sistēmu, bet es esmu pārliecināts, ka tur var atrast zeltu, mans draugs... lūdzu, atbildiet man kāds...
 

William D.

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Domāju, ka tas nav piemērots šai tēmai. Mums ir daudz pētījumu par dizaineru noīdiem. Un klasisko struktūru ir daudz vairāk, nekā jādomā par pilnīgi jaunām. Jūs varat rakstīt man savas idejas un kopā ar komandu piedalīties noīdu projektēšanā.
 

itarus1993

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Kāds var man sniegt informāciju, lai iegādātos visas lietas, ko darīt jwh-18 ES, es nevaru atrast dažas ķimikālijas PM lūdzu
 

VenditorPulverum

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Hey there,

What is the percentage yield of 3-(1-naphthoyl)indole that you obtained from 1-naphthoyl chloride? I'm curious of this because I am running a similar reaction involving SnCl4. Thanks!
 

William D.

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Are you using nitromethane for this reaction? It's a must. Stannous chloride anhydrous? Using aluminum chloride is actually easier.
 

VenditorPulverum

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No I am doing a Friedel-Crafts alkylation of benzene with chloroacetone. I'm using SnCl4. Yes, that nasty fuming liquid because I can't make AlCl3 in great quantities. I was curious what were your yields with this procedure because it's the same reaction after all.
 
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William D.

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The tin of chloride with the indole complex is not dissolved in dcm, you need a sufficient amount of nitromethane so that it is dissolved. This is the main problem. And if you synthesize the catalyst yourself, how do you dehydrate it?
 

VenditorPulverum

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I make it with dry chlorine gas under anhydrous conditions. Accidental moisture ingress produce only a very tiny amount of pentahydrate crystals, which get left behind after redistillation. Solubility is not a issue in my particular. So do you have a ballpark figure for the percentage yield of the first reaction, based on the 1-naphthoyl chloride? This information would be very useful to me. Thanks!
 

DreamsandAmines

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Hey, the sn2 reaction will not carry out well with water right? Can we use methanol instead? I am quite sure that the second step will not work unless anhydrous.
 

William D.

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Yes, the conditions must be completely anhydrous. It is not necessary to dry the solvents completely, but it must also be dry initially. Methanol will not work, nitromethane is required for this method.
 
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