2C-feniletilaminų sintezė

[NarwhalFucker419]

Ar kas nors turi informacijos apie 2C-H bromavimą n-bromsukcinimidu? Mačiau, kad keli žmonės apie tai užsiminė kitur, bet neradau jokių aprašymų.

 

[Raxmil]

Aš irgi to ieškau, bet nepavyko rasti išsamios informacijos
Žinau tik tiek, kad galite tai daryti GAA arba DCM, bet neturiu supratimo apie santykį

 

[amieri]

There's a person in maybe theehive on Reddit.i believe the also have a mescaline synth posted too and a few others.

 

[btcboss2022]

Man kyla abejonių dėl paskutinio 2CB sintezės etapo. Ten rašoma: "Reakcijos mišiniui buvo leista grįžti į kambario temperatūrą, jis buvo filtruojamas, o kietosios medžiagos taupiai plaunamos šalta acto rūgštimi." Kol žinau, kad acto rūgštis tampa kieta 16-17C temperatūroje, tad ką tiksliai reiškia šalta acto rūgštis?
Ačiū.

 

[G.Patton]

Sveiki. darau prielaidą, kad šalta rūgštis reiškia kambario temperatūrą, nes yra paaiškinimas, kad reakcijos metu išsiskiria šiluma.

 

[btcboss2022]

Gerai, gerai, aš irgi taip maniau, bet norėjau pasitikslinti, nes žinote, kai sakome šalta, paprastai turime omenyje iš šaldiklio, o ne RT hahaha, bet su acto rūgštimi tai neįmanoma ;-) ačiū

 

[w2x3f5]

Nelabai suprantu, kodėl plaunant amino hidrobromidą, jo neįmanoma naudoti, jis dega. Geriau išgryninti ir gauti hidrochloridą, o nuostoliai mažesni, kaip išvengti abejotinų bandymų plauti miltelius iš bromo.

 

[nujrc]

Suprantu, kad likęs elementarusis bromas iš produkto, kaip ir bet kuris tirpiklis, išgaruoja ore, todėl laikui bėgant neliks jokio pagrįsto kiekio. Gaminant HCL nedžiovinant HBr - sėkmės norint gauti grynesnį produktą, nes gali tekti susidurti su bromo druskomis, esančiomis bromo/GAA tirpale, ir pačiu bromu.

 

[w2x3f5]

Nematau jokių problemų sumušti bromo likučius su tiosulfatu, paskui atvesti ph iki šarminės terpės ir surinkti aliejų su tirpikliu.

 

[situ1984]

(R)-(+)-α-metilbenzilaminas CAS numeris:
3886-69-9 Ar tai iš plaučių? O gal jis absorbuojamas iš skrandžio? Ar jį galima vartoti tiesiogiai?
(R)-(+)-α-metilbenzilaminas CAS numeris:
3886-69-9 Ar jis gaunamas iš plaučių? Ar jį absorbuoja skrandis? Ar jį galima vartoti tiesiogiai?

 

[G.Patton]

Jis neturi psichologinio poveikio.

 

[amieri]

Kur gauti 2,5 dimetilnitrostireno

 

[HerrHaber]

Henrio 2,5-dimetoksibenzaldehido kondensacija su nitrometanu, esant pirminiam aminui kaip katalizatoriui.

 

[amieri]

It blows my mind how far I've come in this since I wrote this . You guys are all works of inspiration thanks for sharing

 

[taricshop]

ar įmanoma 2cb sintezėje elementarų bromą pakeisti hbr rūgštimi?
@G.Patton

 

[Newbee]

@HEISENBERG @WillD @G.Patton
Question to you guys.Is it possible to perform bromination of 2ch to 2cb by NBS (N-Bromosuccinimide)
instead of elemental bromine (br2)

 

[G.Patton]

Hello.
Yes, I think so.

 

[amieri]

That's seems to be the new go to I see alot.i need to get some succinimide acid n give it a try.

 

[Newbee]

i found some writeups on thehivee but im not sure about it i also cant try do it on my own. but NBS seems to be safer to use than BR

 

[amieri]

I use a 2×2×4 grow tent in its side with a 8" inline fan going out the building as a hood up on a folding table definitely does the job,still wear a mask non the less. Make sure you have a 5% sodium thiosulphate solution on hand in case of a accident and a rubber made bin with enough of that solution to run through you glass at the end.and think every step out. You got this my friend can't wait to hear of your success.

 

[Swirly]

Yes, you can brominate with NBS on 2c-h HCl, you can read in my post.
You could even risk NBS bromination on 2c-h freebase in DCM or on the oxalate/sulfate salts.

Have a read:

https://bbgate.com/en-gb/threads/a-mostly-kitchen-friendly-synthesis-of-2c-b.13198/#post-73488

 

[amieri]

Sure you can, obviously dig as deep as you can researching hand but the fact you came this far says a lot.so keep pushing and if you waste something you at least gain the experience.now safety if thats what your concerned about thats a horse of a different color

 

[Rabidreject]

I just wanted to say thanks for this incredibly involved set of syntheses.
It is really impressive.
It’s funny, I made quite a few different nitrostyrene’s and nitropropene’s and then when I started reducing them and getting decent yields on active molecule’s, I started thinking okay, well it can’t be that much harder to produce the 2c-x compounds, then you see people making 2c-b and presumably other haloginated 2c’s and you think ah okay.

Then you start digging into the alkylated 2c compounds and my oh my does the chemistry take a jump in complexity!!

Anyway, I’m pretty convinced that my next major project is going to have to be the ethylated 4 position.
Is that a friedl-crafts alkylation you do to the 2,5-dimethoxyacetophenone, I mean in order to get from that to the 2,5-dimethoxy-1-ethylbenzene?

I think the most annoying part of it is that I’m going to have to get a vacuum pump that runs to super high vacuum!

Anyway, be prepared to be bugged by me a lot in the coming months/years because once I set my mind to something, I WILL learn how to get it done. It often involves harassing old posters! Ha