Mefedrooni süntees (4-MMC) NMP lahustis. Suures mahus.

[bubuka]

Tahaksin valmistada MMC-d NMP-s. Probleem on selles, et mul puudub pH-paber. Kui problemaatiline on see, kui ma lõpus üle hapestan? Või oskate öelda, kui palju 30% soolhapet peaksin 100g 2b4m kasutamisel lõpus lisama? Hapestan DCM+vees.

 

[William D.]

Kui teil ei ole piisavalt kogemusi, peate maksimaalse saagise saamiseks kasutama indikaatoreid. Kui see ei ole võimalik, saame teile arvutada minimaalse happekoguse, mida saate toote saamiseks lisada.

 

[TheVacuumGuy]

Kui ostate elektrilise, tehke endale teene, kui kulutate lisakulu, et saada klaasproov. Vastasel juhul lahustub see (jah, olnud seal)

 

[c01db100d_india_mephedron]

kas me saame asendada
soolhapet 48% vesinikkloriidiks
kui see on võimalik, kui palju toote saagist ja kui palju me tahame saada

 

[William D.]

Jah, seda asendust saab kasutada. Toote kaal on samadel tingimustel veidi suurem.

 

[c01db100d_india_mephedron]

Täname teid väärtusliku nõuande eest
@Dr. MMX @WillD @G.Patton

 

[c01db100d_india_mephedron]

HCL (36%)
Cas nr. Plz

 

[Hanna520]

Miks kasutada benseeni ja NMP-d. Kasutage selle asemel etüülatsetaati. Palju ohutum. Vahetage monometüülamiini aqua alkoholi baasil.
Pärast vee lisamist. Eraldage kihid. Võtke "õli" kiht ja destilleerige EA ära. Rasvem see samm. Jahutage baasõli 1 tunni jooksul külmas -19. Reageerimata kõrvalsaadused tulevad. Filtreerige lahus ja pange alus AC ja HCL37%-ga lisage pH 5,5.

Ärge kasutage kuumutamiseks leeki. Kasutage selle asemel vanni. See seadistus annab teile häid tulemusi. )

 

[momogf]

Hea viis, kuidas ma tegin ise 2bromo4metüleenopropiofenooni

 

[dnBQByvHb8Zkawbjpx]

Seda arutati paar päeva tagasi peavestluses. Üldine soovitus oli, et EA-destilleeriksime ära 55 °C juures vaakumis (/negatiivse rõhu all), et saagis oleks parem. Kas te mõtlesite seda või pidasite silmas destilleerimist normaalsel rõhul 77 °C juures (EA keemistemperatuur)?

Ma loen sellest esimest korda ja ma proovin seda.

Ma alustan teemat 4-MMC saagise maksimeerimise kohta ja kutsun teid oma teadmisi jagama. Tundub, et te teate sellest palju.

 

[William D.]

Jah, etüülatsetaatmeetod on hea, kui teil on metüülamiini alc. soln. See lahendab paljud probleemid.

 

[Germanium]

Kas soolhappe lisamise asemel on võimalik kristallisatsioonietapis vesinikkloriidigaasi mullida?

 

[dnBQByvHb8Zkawbjpx]

Jah, see on hea alternatiiv soolhappe kasutamisele, kui te pidasite silmas "hapestamist", mitte "kristalliseerumist". Kristalliseerimise käigus ei lisata hapet.

 

[Germanium]

Suur tänu teile!

 

[goku1008]

but in video no Benzene used

 

[CARLITOBRO]

can we replace NMP also with ethyl acetate and if yes how much for 100gr of 2b4m

 

[HIGGS BOSSON]

Yes, you can use NMP, DCM, ethyl acetate
bbzzzsvqcrqtki6umym6itiixfhni37ybtt7mkbjyxn2pgllzxf2qgyd.onion/en/threads/mephedrone-4-mmc-synthesis-from-haloketone-in-ethyl-acetate-1-10-kg-scale.39/unread

 

[baadwd332]

Hey, thanks for sexy video.
I wonder if you know Perrine paper about bupropion synthesis in NMP (Im sure you do, apparently he got an idea to use NMP).
If not, here you go:

Perrine, D. M.; Ross, J. T.; Nervi, S. J.; Zimmerman, R. H. A Short, One-Pot Synthesis of Bupropion (Zyban®, Wellbutrin®). J. Chem. Educ. 2000, 77 (11), 1479– 1480, DOI: 10.1021/ed077p1479


If you carefully read SI you will see that they had to wash out methylamine from organic layer. Had to be couple of times of water washing. In your procedure you don't even wash organic (benzene) layer, thus I wonder if you ever check melting point? Seems it might be mix of 4mmc and methylamine hydrochloride.

 

[William D.]

In the synthesis that you wrote about, a large excess of pure amine is used. In our synthesis, an aqueous solution of amine is used. This changes the conditions. If you use more than two flushing, you will lose a lot in the weight of the product. The amount for several grams and quantities for several kilograms always change conditions, especially in the amounts of solvents and flushing water.

 

[wikimiki]

What if I gonna replace NMP with DMF? Somebody tried? What proportion of DMF should be used if in use instead DMF?

Somebody have the stirring timings and than other timings for those synthesis description? It looks very interesting, I will be appreciate.

 

[William D.]

DMF can be used like DMSO, but yield and some other conditions may differ.

 

[wikimiki]

William thanks a lot but could you tell me how much differ your recipe if I put DCM and what need to be changed if I put as someone said below DMSO and Toulene? I will be appreciate. With highest respect for the recepture you have posted I cannot get how in large scale production the 40-50% of yield can satisfy you?

Best regards

 

[William D.]

For the test, you must mix BK4, dcm and methylamine as usual. You can add the amount of DMSO until the mixture becomes homogeneous. In this form, the reaction will be faster than usual. You control the reaction for the first time in temperature (when the mixture begins to cool, the reaction is finished, even without additional heating). After you add pure cold water and separate the lower layer and rinse again. Further steps are the same as you used (acidification with acetone or into the water layer)