Phencyclidine (PCP) synthesis

[tripeep]

in scheme 4, how does it mean to treat with sufficient ammonium hydroxide and a saturated solution of NH4Cl until the precipitate dissolves. and how much weight is needed?

 

[G.Patton]

 

[tripeep]

???

 

[G.Patton]

Sorry, there was a bug.

 

[the money]

 

[wish690]

"Note that use of phenyl lithium instead of phenylmagnesium bromide results in failure via addition to the nitrile rather than displacement. However, in the presence of a Lewis acid, phenyllithium will displace the nitrile group and yield the desired product. Primary amino analogs of PCC, such as N-ethylamino cyclohexanecarbonitrile will produce the desired PCP analogs by reaction with 3 moles of phenyllithium.
"

What does it mean? Is Lewis acid required for PCE and other primary amino analogs with nitrile method and phenyl lithium? Or is it only for PCP? Which Lewis acid is best?

 

[G.Patton]

A guess so, AlCl3 is suitable in this case

 

[wish690]

AlCl3 must be dropped in phenyllithium before nitrile? How much?

 

[G.Patton]

The catalytic amount, I suppose.

 

[wish690]

I'm just wondering if that chlorine salt won't destroy phenyllithium.

Can't find any info where it's necessary, besides this tek.

 

[G.Patton]

Hi, I can't ensure this because we haven't check this way with phenyllithium.