Mephedrone (4-MMC) synthesis; easy to perform- high yielding

[tucoXxX]

I want almost 1 kg of finished product. can I make it 3x the amount of reagents?

 

[olduser]

better to take x4 : 2Kg of bromoketone, some people don't even reach the 50% yield + if you want it in crystal form, your yield decrease

 

[w2x3f5]

there is not enough solvent, 2.5 hours is too much and the temperature too high, the substance turned out to be very dirty after adding the acid.

 

[SonicNL]

The temp and time are right. You must have made a mistake.

 

[ghostimage]

28-32с, 1h40min, full reaction so i agree with you, i am a bulk manufacturer, make minimum of 15kgs in one turn, so this parameters cost me about a year of experiments, and you here give it to people, who just dont belive you....ahahahah what a lol ;(

 

[HerrHaber]

I recently achieved a greater than heard of yield of 4MMC hydrochloride in a moment when I expected it the least. Before I make it public to everyone I feel more than just 5 runs are necessary (out of 5, 2 consecutive were high yielding then 2 I thought I would improve but didn't, and another make's the triplicate required for me to state this). However I did run out of stuff and I'm looking forward to completely document this with pictures and all that. And not to be judged for holding back the "precious" information, I can trade off some counterintuitive details of the preparation:

-stirring is key (to keep DCM and water layers in the most intimate contact without phase transfer catalyst)
-relatively long reaction time (about 6 to 8h, I use taking a break by just pause the stirring assuming that if the layers are separate the reaction is almost halted)
-no heat applied (my third and fourth run had average and below yields when gentle heating was applied)
-cooling the mixture and reagents (at the acidification step chilled liquids were the best yielding)
-filter quick (just after the solids precipitate, do not let stay as part of the product will go in solution)

Hope this will help and I promise to be back with details and why not, a validation from another active member.

 

[mcdonalds]

hello,
i'm not sure why condenser is used in this syntessis.
is correct that is for condense methylamine gas and keep it in the reaction

 

[Naruto]

No

 

[olduser]

yes, but as methylamine is already in excess I guess it's used to reduce the smell

 

[HerrHaber]

yes, but harmful even more so

 

[William D.]

If you use cooling with liquid nitrogen, the reaction mixture in the flask would simply freeze . Therefore, only an excess that is filtered or evaporates into the atmosphere

 

[Ranbir Singh]

How can change mephedrone powder to crystel form please tell me

 

[dnBQByvHb8Zkawbjpx]

Using the process called crystallization: http://bbzzzsvqcrqtki6umym6itiixfhn...n/threads/mephedrone-4mmc-crystallization.72/

 

[agness]

Can I use a Ethyl acetate instead of Dichloromethane?

 

[olduser]

Yes

 

[lucky2222]

hello thank you for info knowledge was wonder on the sop if you had methylamine HCL instead of methylamine 40%aq what step would you use instead to make it a liquid ? thank you again for your time

 

[William D.]

@lucky2222 there is a lot of information on this forum about this. You can use water or alcohol with sodium hydroxide or triethylamine to produce gas. Triethylamine is more convenient in some cases if it is available to you.

 

[Blazey]

nice, i missed out on this chem before the bans in the uk, glad to see its around still, i wanna try it me as I love mdma

 

[lucky2222]

hello was wondering if there away to substitute methylamine 40%aq with methylamine hcl in this sop ?

 

[Rhales]

Sry I don't understand clearly your question. The addition of water is used to dissolve the polar impurities in the solution after the reaction (2B4M, methylamine, etc). You need to let it a few minutes then throw away all of the water, only the oil stays.
You can addapt the protocol to 3mmc aswell, you need to use 2-bromo-3-methylpropiophenone as main reagent and keep the same molar ratio (as they are isomers, you can keep the exact same amounts).

 

[olduser]

Sry I don't understand clearly your question. The addition of water is used to dissolve the polar impurities in the solution after the reaction (2B4M, methylamine, etc). You need to let it a few minutes then throw away all of the water, only the oil stays.
You can addapt the protocol to 3mmc aswell, you need to use 2-bromo-3-methylpropiophenone as main reagent and keep the same molar ratio (as they are isomers, you can keep the exact same amounts).

 

[Rhales]

If it's your first batch, I recommend using protocols that has been written by the forum experts. These are good too but hasn't always been tested and are more about experimentation once you already know the synth. WillD threads about mephedrone are really good

 

[olduser]

If it's your first batch, I recommend using protocols that has been written by the forum experts. These are good too but hasn't always been tested and are more about experimentation once you already know the synth. WillD threads about mephedrone are really good