LSD synthesis from Ergotamine

[ieatfungi]

Yoyoyo could anyone perhaps assist me in locating some ergotamine tartarate or containing medicines in the U.S? Any assistance is appreciated

 

[amieri]

Ever have any luck

 

[Sneaky.Base]

3 grams of lsd gives 20000 to 30000 doses , excuse my noob question, how did they separate this exact small quantity to blotter on 30000 doses?
Tnx for any reply

 

[amieri]

By making a solution in distilled water or ethanol.each 1/4"×1/4" tab of blotter can hold x amount of liquid

 

[Macondor]

Boss I buy a LSD solution, 100mg in 5ml of vodka and i want to store indefinitely. Have some questions..
-Is better in the freezer or in the fridge?
-Is neccesary to bubble argon or nitrogen to the solution and fill the empty top part of the dropper with the inert gas or vaseline or something like that?
-Put a few mg of EDTA?

Thanks!!!

I want to store for years.

 

[G.Patton]

Keep receptacle tightly sealed. Store in cool (use -17-20 *C freezer), dry conditions in well sealed receptacles.

 

[Macondor]

thanks man, so is not neccesary do anything of what i described?
The vodka solution hermetic in the freezer and nothing more?
If in the droper have a a little space with air because is not full is not a problem?

love

 

[G.Patton]

I think it would be enough.

 

[GhostBlack]

How can I create an inert atmosphere? What devices do I need?

 

[UWe9o12jkied91d]

Here, I have illustrated a classic inert gas reaction setup. You can follow the flow of N2 to the condenser where it eventually gets pushed out, ensuring little to no oxygen can enter.The flow must be calibrated as such that nitrogen does not push out reaction products or solvents that we don't want pushed, to this a end a bubbler can be attached between the canister and flask to visualize the flow of gas.N2 is used in this way in official settings since it is readily available and cheap, but also light, so it needs to be flowing to not be replaced with athmospheric air.
We need only to use our imagination to apply this to our amateur setting.A gas that is inert and by contrast to N2 is much heavier is Argon, it is more expensive and is much rarer, but available.Argon can be used this way by only filling your reaction medium using a canister and optionally pulling a vacuum at the end of the condenser and refilling with argon.

 

[GhostBlack]

Thank you very much for the information

 

[G.Patton]

Inert atmosphere synthesis and distillation

 

[Nicoino]

Could lysergic acid methyl ester be used instead of ergotamine?
Would the basic condition hydrolize the methyl ester?
If this works the rest of the procedure would be the same.
Using methyl lysergate would make LSD synthesis really user friendly and cheap.
Any advice is appreciated

 

[archae]

Yes, you can hydrolize under the same conditions to cleave the additional groups

 

[Nicoino]

Thanks for the confirmation, may try in the future when I will have some money to invest in the process

 

[ZACARIASKLK123]

@G.Patton

Hi, can ergotamine tartrate be changed for "Dihydro Ergotamine Mesylate --> 6190-39-2"?

Adjusting molar ratios and such (obviously).

Perhaps we would obtain Lysergic acid diethylamide (LSD) mesylate? Or am I wrong?

 

[G.Patton]

Yes, you can
You won't get LSD mesylate if just substitute ergotamine salt. You need to change acid in the last step. I'm not sure that you can get LSD mesylate in practice.

 

[HerrHaber]

If done the chemist way, it should end up with nor-LSD but not mesylate salt. Ssince the product is closer to neutral (amide) but more basic than LSD due to the fact that it has a proton instead of methyl on the quinoline moiety nitrogen atom.

 

[NoraJean]

Anyone know how to go about sourcing ergotamine?

 

[PlanckB1]

Hello,

What solvent would you use for the purpose of recrystalising the D-Lysergic Acid Hydrate? Would ethyl acetate be suitable?

I also have a similar question for the recrystallisation of the lysergic acid diethylamide tartrate if there are any other solvents which the salt would have similar solubility to methanol?

Thank you very much

 

[nutella]

@G.Patton can I use something other than diethyl ether (Et2O) in step 1 for washing? Thanks

 

[G.Patton]

Dioxane and, probably, petroleum ether.

 

[nutella]

and for the d-Tartaric acid is 147-71-7 or 87-69-4 the correct CAS? Thanks

 

[G.Patton]

d-tartaric acid cas 147-71-7
l-tartaric acid cas 87-69-4
easy to google