One-pot Amphetamine Synthesis From P2NP With NaBH4/CuCl2 (1kg scale)

G.Patton

Expert
Joined
Jul 5, 2021
Messages
2,704
Solutions
3
Reaction score
2,858
Points
113
Deals
1
Temperature and pH have a strong influence on the reaction yield. You have to control temperature as described in the manual. Also, you should carry out acidifying very slowly to save your product. It also can cause side-products formation.
 
Last edited:

Mystery_chemistry

Don't buy from me
New Member
Joined
Jun 12, 2022
Messages
82
Reaction score
32
Points
8
oki then what should the pH be before adding the base? according to the bars, there are 10 in 100% and I even think that more: / even if it goes up to 14, something will happen?

at the temperature won't it be better to keep all reactions in those 55-60? when reducing aluminum amalgam the temperature is so, why are we given a higher temperature here?
 

Bartholomeus

Don't buy from me
New Member
Joined
Jun 23, 2022
Messages
127
Reaction score
68
Points
28

Do you already have any experience with this reaction?
Or did you already had any success with this reaction?
What was your yield?
 

G.Patton

Expert
Joined
Jul 5, 2021
Messages
2,704
Solutions
3
Reaction score
2,858
Points
113
Deals
1
It's okay, pay acidification procedure
because here is different reaction, there is no amalgam
 

Mystery_chemistry

Don't buy from me
New Member
Joined
Jun 12, 2022
Messages
82
Reaction score
32
Points
8
I know, but I mean more about p2np which has a melting point of 63-65 degrees ... hence my question whether the reaction at 55 degrees throughout the reaction time will not be a better solution ...
 

Mystery_chemistry

Don't buy from me
New Member
Joined
Jun 12, 2022
Messages
82
Reaction score
32
Points
8
well ... how to know that everything reacted and the reaction is over? I suggest copper chloride sink to the bottom… a good way out?
 

chemutil

Don't buy from me
New Member
Joined
Aug 14, 2022
Messages
1
Reaction score
0
Points
1
If I understand correctly how P2NP is reduced to amphetamine, NaBH4 will reduce the -NO2 group and the alkene group. But I don’t understand what the role of CuCl2 is. Please explain how this mechanism works. Thank you in advance.
 

G.Patton

Expert
Joined
Jul 5, 2021
Messages
2,704
Solutions
3
Reaction score
2,858
Points
113
Deals
1
Hi. CuCl2 Works as catalyst in this reaction. Do you need more detailed explanation?
 

Mystery_chemistry

Don't buy from me
New Member
Joined
Jun 12, 2022
Messages
82
Reaction score
32
Points
8
Hi, I wonder if the reductions can be made on the water only? after alkalisation, pour in a non-polar solvent and pull out the free base. it is possible ?
 

WillD

Expert
Joined
Jul 19, 2021
Messages
774
Reaction score
1,054
Points
93
click. Steps 1-5 are better in waterless conditions (with one equivalent of NaBH4). After, with the resulting nitropropane and metal chloride as catalyst, water conditions are possible.
 

MisterAnonymous

Don't buy from me
Resident
Language
🇺🇸
Joined
Sep 3, 2023
Messages
98
Reaction score
46
Points
18
@William Dampier what is the BP of Amphetamine Freebase and does it need to be distilled under vacuum?
Or does steam distillation also work?
I just want my Freebase colorless like water!
 

KokosDreams

Don't buy from me
Resident
Joined
Aug 16, 2022
Messages
912
Solutions
2
Reaction score
599
Points
93

What's the maximum liters of reaction mass you would load into your 100L glass reactor?
 

mithyl2

Don't buy from me
Resident
Language
🇬🇧
Joined
Aug 19, 2022
Messages
264
Reaction score
27
Points
28
is this the correct cas number for the P2NP: 705-60-2

will any other cas numbers work?
 

mithyl2

Don't buy from me
Resident
Language
🇬🇧
Joined
Aug 19, 2022
Messages
264
Reaction score
27
Points
28
and what % Sulfuric acid should be used?
 

KokosDreams

Don't buy from me
Resident
Joined
Aug 16, 2022
Messages
912
Solutions
2
Reaction score
599
Points
93

That is the correct CAS number, I would recommend you to stick to this one.

You can contact Constantylious777 from the forum, he's selling good quality P2NP, also there are other clearnet vendors that offer this product.
 

mithyl2

Don't buy from me
Resident
Language
🇬🇧
Joined
Aug 19, 2022
Messages
264
Reaction score
27
Points
28
thanks for letting me know
 

KokosDreams

Don't buy from me
Resident
Joined
Aug 16, 2022
Messages
912
Solutions
2
Reaction score
599
Points
93

You are welcome!
 

WinterDust

Don't buy from me
Resident
Joined
May 21, 2022
Messages
229
Reaction score
207
Points
43
Deals
3
Hi, have some questions about the synthesis.

6. 25% water solution of NaOH (8 liters) was added to reaction mixture and the phases were separated.

Q: You ad the NaOH to the synthesis and it splits into two laywers, and you drain the bottom layer and keep the upper layer?

7. The aqueous phase was there after extracted with 8 liters of IPA.

Q: I don't understand this part, after separation from step 6 you ad 8l of IPA and mix it?

8. IPA was evaporated on vacuum to an oil.

Q: Can I use a homemade small distiller to evaporate the IPA? And at what temperature should it be evaporated 60C?

9. The oil was dissolved in two liters of acetone.

Q: I don't understand this part, you ad the acetone to the oil and then start with the sulphuric acid step to get it into the right pH?

Bdst regards
 

tucoXxX

Don't buy from me
New Member
Joined
Sep 29, 2022
Messages
83
Solutions
2
Reaction score
11
Points
8
hi I am looking for answers to these questions. if you got it, can I see it? I'll go through the thread to see if I can find it.
 

Curiousonion

Don't buy from me
Resident
Joined
Aug 29, 2022
Messages
190
Reaction score
69
Points
28
Isn't sodium borohydride expensive?
And at 3 kilos to produce 1 liter of amphetamine oil the cost would be a bit too much for it to be attractive.
 

antrax

Don't buy from me
Resident
Joined
May 14, 2023
Messages
163
Reaction score
56
Points
28
Did you finally synthesize amphetamine sulfate (speed) following this route?
 
Top