Mephedrone (4-MMC) synthesis; easy to perform- high yielding

[K-Cyanide]

Congrats, so your product looks like this after the reaction time is over and before any washing/cleaning, correct? If so, we all are curious about your mysterious method to obtain a super clean product out of a reaction, which is per se not clean with a couple of side reactions.

 

[cartelloszetas]

I dont wash nothing i throw acid and aceton mix and get this all.u need know what u do freebase i made in 30min

 

[ice4mmc]

Serve Wickr.me/singal/tegram Need answers to questions, pay reliably, or establish collaboration

 

[thevines2]

Well if I make my 4mmc too pure and not stimulating I'd prob just go 2009-10 style and mix methylone with mephedrone got some amazing highs off that combo over years

 

[Cruela83]

Do you remember how many milligrams of methylone and how many of mephedrone was that combo?

 

[WildDoc]

Is rotovap must have in this reaction?

 

[UWe9o12jkied91d]

no

 

[Osmosis Vanderwaal]

A rorovap is not a requirement in any reaction. Vacuum distillation accomplishes the same goal but is just less convenient

 

[The Alchemist]

@thevines2: This is how I feel too. I don't care how much better dirty drugs are, it's better to compensate with a second pure substance. Dirty drugs are just multiple unknown substances anyways.

@K-Cyanide: How do I know you don't got unreacted precursor, side products and HCl in your product? Oh right, you do, that's why it's so much better. You can huff drain cleaner too and that will feel nice but should you??

Make a pure product. No one likes it? Boohoo make something else they like and do it right. You can make meth in a fire extinguisher with old batteries, but should you??

You're so good why don't you isolate the isomers and sideproducts, bioassay then send to mass spec? This furthers study and let's you know if you're offering your customers bad product. Do you care about that or is this money for you?Rhetorical.

Your method is bad. Everyone knows it. So do you. You got a "good enough for the street" attitude and I find it offensive. You probably cut it with caffeine and baby formula too, huh? Your 4mmc isn't stimulating? You forget the R isomer or something? I seen nice 4mmc crystals but you got tan powder that you call 99% that isn't stimulating? You're a liar and a street pusher. Every step of your method is trash, that's why I see this thread show up every day calling out your mistakes and your poisonous way of life. Very fitting username, brother. You knew what you were doing lol

So, I wonder, what's better, ciggerettes or nicotine?

 

[Osmosis Vanderwaal]

If there was very much unreacted precursor it would rip the flesh off of your face. Just smelling it gently is very painful that's probably the 1mg mark or less

 

[Osmosis Vanderwaal]

Also, what drain cleaner feels nice? I have HCL+H²O, H²SO⁴, & NaOH. I will get it if it is something else, but you've left me intrigued. Thanks for your valuable contribution!

 

[OrgUnikum]

I do not believe this is gospel. Personally I can say that with dextro-Methamphetamine.HCl and with Amphetamine salts there is a lot to gain from removing even the smallest impurities. The gains are in "clearness of mind" and in an very easy comedown. Of course one might have another definition of "desired effects" which got defined by the use of the usual crap of trade which has turned Amphetamine into a deliriant, but honestly, thats not my problem.

With 4-MMC I have some feeling there might be a sidereaction involving the carbonyl moiety, in special when an excess of Methylamine is used. Also I am a bit surprised that nobody bothers with removal of bromine when the color shows clearly that shitloads are still present (red/pink), No bisulfite, thiosulfite or charcoal, why not?

@DavidNichols There is no Reductive Amination. It is a Substitution.

Everybody kindly start cutting the others some slack and also everybody stop posting "ex cathedra" "speaking for god". In the end we all cook only with water and it is not about "winning" ok?

thx

 

[w2x3f5]

an excess of nucleophile (methylamine) reduces the likelihood of a reaction of the secondary amine with bromoketone, since the secondary amine is more reactive.
with the condition that he took dry bromoketone, most likely there was no free bromine, but the color of the solution clearly indicates a large amount of impurities in the original bromketone.

 

[OrgUnikum]

Of course there is bloody Bromine in there, you see it!
Simple as is: Add some thiosulfate in water to the reddish solution until it turns colorless. Bromine was turned into Bromide.

You will find that every reaction involving Bromine has such a step involved, those which have not, use purification by chromatographic column as followup step.

Also I would bet that the Methylamine as primary Amine is more reactive, much more reactive then the Methcathione as secoondary Amine, not to talk about highly probable steric hinderances.
I have problems though to comprehend why Methylamine should not react with the Keto-group what would be not a problem as long the bromoketone is already transformed into a secondary Amine as then only the Imine is formed which will revert on contact with some water, but if this happens on the bromoketone the Amine will form and the Bromo replaced by a OH-, Hydroxyl....

 

[w2x3f5]

Such colors may also be due to adverse reactions, but it is undoubtedly worth washing the bromoketone with sodium tylosulfate or testing for free bromine. I believe that most likely it is either dibromoketone and/or partial bromination into the ring.
Secondary amines are more reactive, and methcathinone has steric hindrances. So that you have a better understanding of this reaction, I recommend that you study the analysis of impurities in mephedrone; there are a large number of scientific works with the analysis of impurities. Briefly, they detect impurities of self-condensation of cathinone (the final product is imidazole), condensation of cathinone with bromoketone, I did not see the formation of imine by the condensation reaction of cathinone with methylamine.

 

[41Dxflatline]

I've only done it once on a very small scale and there has been no trace of orange in either layer. Infact at first I thought I'd fucked up because I see a lot of photos with orange on here.

 

[HOLLANDSFINEST]

very clear topic, thanks for sharing this knowledge

 

[Mehdi]

can somebody send me the method?

 

[Jordan Belfort]

brother why you don't freebase the 4-mmc and destill incase of rotovap ?

What is the boiling point under freebase and vacuum do you know

 

[w2x3f5]

you need a very strong vacuum of the order of 10 microns, the free base of mephedrone self-condenses very easily, accordingly, the boiling point is needed at least less than 100 degrees, and even better even lower.

 

[TheVacuumGuy]

@K-Cyanide
Thanks for this detailed procedure. IMHO it's one of the best here actually.

 

[Woody]

Hello guys. I got new chems and with these my last known synthesis with brom toluene and metil doesnt work. 4chlorophenyl-1-bromoethyl-ketone, for solvent dcm. After reaction I trying to acidify, but no flour drops.. I stoped mixing, and there was 2 layers I take them in separate containers, and one of container started crystalization.. I got not much about 10% crystals, and much greasy stiky yelowish paste... Can someone take me on the road?

 

[The-Hive]

Upload some images mite not off reacted long enough