Hello, It is my first time to post there.I apologize if it is not proper.Recently, I got some Ritalin acid and want to make methylphenidate not use HCl because I can't get it directly.Could anyone help me?
How to synthesis methylphenidate from Ritalin acid
- Thread starter untryrgos
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You must perform an esterification reaction with methanol, this is usually done with sulfuric acid as catalyst but I trust you will find the preparative writeup around here. If you can get your hands on sulfuric acid you will also be able to make HCl.
Most probably yes, but concentrated sulfuric has much less water in it and esterification is an equilibrium reaction where the water resulting from the reaction of the alcohol with the ritalinic acid also has the power to hydrolize the very same bond. This is conventionally accomplished by using a large excess of the alcohol which can serve as the solvent or in other words medium of the reaction. What I want to say is that yield will certainly be affected.
bbgate.com
I do trust the author of this thread, he's a competent chemist.
Methylphenidate (Ritalin) synthesis
Introduction Methylphenidate (Ritalin; Concerta) synthesis method can be learned in this topic. It is the simplest way to produce this substance which isn't taking any elaborated glassware, equipment and special conditions such as high pressure, inert atmosphere or extremely low or high...
bbgate.com
I do trust the author of this thread, he's a competent chemist.