Ketamine & Amphetamine
Ketamine & Amphetamine are two substances from different groups that have different mechanisms of action and effects when used in combination.
Amphetamine increases the level of certain neurotransmitters in the brain, mainly dopamine and norepinephrine. This leads to increased alertness, concentration, and energy.
Ketamine, on the other hand, is a dissociative anesthetic that works by binding to a specific type of glutamate receptor (NMDA) in the brain. It works like a non-competitive NMDA receptor antagonist. It blocks the work of NMDA receptors, which are involved in the passage of signals between neurons of different parts of the nervous system. This leads to changes in perception, including hallucinations and dissociation from reality.
It is worth noting some of the effects of Ketamine, which can create problems when combined with Amphetamine. So, Ketamine causes sedation, respiratory depression at high doses, at the same time an increase in pulse and pressure, nausea, and dissociation. Hallucinations can occur at high dosages too.
Despite the fact that substances work mostly with different receptor systems, Amphetamine stimulation imposed on the effects of Ketamine has potentially dangerous points:
Excessive load on the heart and blood vessels, hypoxia, traumatization, psychotic states.
If you take Amphetamine, and after a while Ketamine, ер latter will block the effects of the stimulant. However, they are very likely to return after reducing the effects of ketamine. This can give interesting sensations, but such swings also give a strong load on the heart muscle
There is an opinion that Ketamine in small dosages can be used at the end of the action of Amphetamine for sedation and a smooth more trip exit. However, this does not cancel the load on the heart and blood vessels.
Ketamine can also reduce anxiety and paranoia, which sometimes occurs from a stimulant. The culmination is in the order of Amphetamine, then Ketamine is also characterized by increased euphoria.
Most likely, it does not need to change the order and add Amphetamine to the already active Ketamine. There is a risk of too intense side effects and the development of unpleasant, nightmarish experiences.
There are reports of psychoses with a complex clinical picture caused by repeated use of this combination.
One of the main rules when using Ketamine and especially its combination with Amphetamine is to minimize movement and physical activity due to problems with movement control, and possible injuries.
This combination requires a lot of experience working with both substances separately, compliance with minimum dosages, rare repetition, and a meaningful approach.
Considering the above, we recommend treating this combination with great caution.
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