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So I was thinking about The synthesis of 4-methyl-propriophenone and I thought to myself, "self, how are you going to get a methyl onto the para position of that benzene?" Then it struck me. Don't do that at all, instead
Friedel–Crafts reaction of propanoyl chloride and toluene
Toluene is methylbenzene, ie a benzene with a methyl substitution. Since Ch3 is a para-ortho director, it should yield 2:1
4-methylpropriophenone : 2-methyl-propriophenone.
Is there a reason this wouldn't work?
Friedel–Crafts reaction of propanoyl chloride and toluene
Toluene is methylbenzene, ie a benzene with a methyl substitution. Since Ch3 is a para-ortho director, it should yield 2:1
4-methylpropriophenone : 2-methyl-propriophenone.
Is there a reason this wouldn't work?