Question 4-methylpropiophenone

[kokkewiet]

Hi, I would really appreciate help with

Synthesis of 4-methylpropiophenone​

Found the video that shows how, by using Propionyl chloride (aq), Toluene and Aluminnium Chloride, but cant find any Propional chloride in our country. Is there an alternative to Propional chloride, or maybe another way of making 4 Methylpropiophenone?

Thanks

 

[BevItUp]

@kokkewiet did you ever get an answer?

 

[kokkewiet]

No, I did not. have you made the methedrone syhthesis yourself before? We did a batch yesterday, (first time) and really need advise as something went wrong with our process. The product burns like hell and its very crystal looking and powdery?

 

[Antihero999]

do you need KU crystal?

 

[kokkewiet]

@Antihero999

We did a batch from the Methedrone Synthesis yesterday, (first time) and really need advise as something went wrong with our process. The product burns like hell and its very crystal looking and powdery?

 

[googie]

Propanoyl chloride CAS Number 79-03-8 Propionilo cloruro

Product name Propionyl chloride Synonyms PropionchloridePropionylchlorid CAS No. 79-03-8 EINECS 201-170-0 Molecular formula C3H5ClO Molecular weight 92.52 Appearance Colorless transparent liquid Melting point -94 ºC Boiling point 77-79 ºC Assay 98%min Packing 25Kg/drum Ap...

www.hbyingong.com

Legit?

 

[BevItUp]

I think it's cool that you've got something you can build on. When you say it burns, does that mean you tried it? Did it do anything?

I was asking about 4 Methylpropiophenone responses because it appears we are going down the same path, and have the same issues.

So presumably you have 2-Bromo-4-methylpropiophenone for your methedrone synthesis, and I'm curious if you found a way to make 4 Methylpropiophenone, which you used to make the 2-Bromo-4-methylpropiophenone? Or did you end up purchasing?

 

[HIGGS BOSSON]

I synthesized 4-methylpropiophenone from toluene and propionyl chloride, which can be obtained from propionic acid.
Reactions are not the most pleasant, so I always recommend buying ready-made 4-methylpropiophenone.

 

[BevItUp]

Kind of a bummer. I want to be able to make everything from what's legally available, but now we're talking 4 levels of indirection

Pretty soon I'll be like some medieval alchemist hunched over a boiling cauldren scrapping reagents from a Basilisk's claw.

 

[The-Hive]

Afternoon do you a link for propionyl chloride synthesis thanks

 

[Osmosis Vanderwaal]

There's several downloads and a nice discussion on the synthesis of propoinyl chloride Here. Mostly the precursors include unobtainable chemicals but not all recipes. I see it is for sale on Ebay if you are brave. When I dream of making it, I dream of the method mentioned on the Wikipedia page using phosgene I can make from sodium hydroxide and acetone

 

[The-Hive]

Bleach plus MEK separate the chloroform then use what’s left over byproducts to propionic acid by the haloform reaction

then use propionic acid to make propionyl chloride with benzoyl chloride

 

[xile]

Whitch continent are you from? I have 4-methylpropiophenone just 1l, but its labor grade. And if you search all possibillitys u can find 2b4mp finished.

 

[Osmosis Vanderwaal]

I couldn't let you guys buy it all. Next, sodium hydroxide drain cleaner and acetone, vacuum distillation, hello phosgene. Phosgene and proprionic acid= hello proprionic chloride, proprionic chloride+toluene=hello 4-methyl-propriophenone. I think that's right.

 

[The-Hive]

We’re getting somewhere on this one..

 

[Osmosis Vanderwaal]

I hope to start this soon. I'm sitting on a bottle of proprionic acid. I'm hesitant to make phosgene at my house, I live in a city and have 2 small children I hope not to poison but I've had no luck getting paramethylpropriophenone in the US. I happened upon this thread , which is great because I couldn't remember or find a synth for phosgene using precursors I could buy. Hopefully this will jolt my memory. When you read 100 pages a day, of synthesis procedures, it gets cloudy, my mind

 

[The-Hive]

Keep us updated

 

[the money]

I wanted to buy 4-methylpropiophenone


So I need to know why it is used in perfumes

When it is detained by customs, I have to give them a convincing answer, so do I know its uses in perfume composition?

 

[the money]

Does any of you have a video about synthesis
4-methylpropiophenone

 

[Osmosis Vanderwaal]

Well there's a video about methylation of propriophenone and there's a video about bromination of 4-mp in the videos of this site bit I don't think there's one for propriophenone, but there are several ways to it.. Friedel-crafts propionyl chloride and benzene, ketonization between benzoic and proprionic acids and a few others, thinking proprionyl chloride and xylene with aluminum chloride maybe I'm currently thinking pretty hard about this. I believe on rhodium a synth from proprionic acid to pseudoephedrine goes through a propriophenone intermediate. Using xylene Starts you off with Para methyls on either end, so for 4-mp, that's a reaction skipped