The synthesis of Ephedrine hydrochloride is proceeding according to Scheme 1.
Scheme 1
Were've carried out 3 synthesis of Ephedrine with 1, 1.5 and 2 equivalents of NaBH4 to methcathinone
Starting reagents and materials for a one synthesis:
10 g of purified methcathinone hydrochloride
40-50...
Introduction
Here is described synthesis method of dl-Ephedrine from 1-Phenyl-1,2-propandion by means of catalytic reduction with hydrogen gas and Adams' catalyst. 1-Phenyl-1,2-propandion Can be purchased in international chemical market, other reagents are not so hard to buy. This is a one-pot...
THEORY OF SYNTHESIS OF EPHEDRINE.
The mechanism of these reactions is well known:
- at the first stage, bromine is attached to propiophenone in benzene, alpha-bromine-propiophenone is obtained;
- at the second stage, bromine is replaced by an amino group, cathinone is obtained (if ammonia is...