Bro, I recently took an interest in chemistry, know very little, bought some glassware and such, , didnt care whenever I was younger, I dabble here and there making nitric acid, tried my hand a couple times at making meth(ruined), watched every videos 20 times, every synthesis is different.. Starts out the same for the most part, foil, amalgam, mercury, p2p solution then change everything up with acids, that said how to do get to the crystallization part, noone ever finishes the video with the shards, just the white product. how do you get the shards? Yes Im that big of a rookie, most will laugh but how do you get the damn shards?
Fear not,here is an example.This is a methcathinone but it works the same way with methamphetamine.On initial isolation your hydrochloride will indeed always come out powdery, recrystalization as you can see in the link below must be performed after filtration and drying of the first crop.
Keep in mind when talking about MA only the D-isomer has the right crystal structure to make large crystals.A racemic mix of the hydrochloride will never form as nice crystals as the isolated D-isomer.
Also in your materials short list I think you are missing methylamine, if you just forgot or have been trying without it idk, but I would try with :^)
bbgate.com
Keep in mind when talking about MA only the D-isomer has the right crystal structure to make large crystals.A racemic mix of the hydrochloride will never form as nice crystals as the isolated D-isomer.
Also in your materials short list I think you are missing methylamine, if you just forgot or have been trying without it idk, but I would try with :^)
Mephedrone synthesis (4-MMC) in NMP solvent. Large scale.
Reaction scheme: Reagents: 2-Bromo-4'-methylpropiophenone (cas 1451-82-7) - 5 kg; n-Methyl-2-pyrrolidone (NMP; cas 872-50-4) - 20 L; Methyl amine 40% aq. solution (cas 74-89-5) - 8 L; Benzene - 20 L; Acetone - 30 L; Hydrochloric acid con. aq. solution (HCl 36%) ~ 1.5 L; Distilled water - 20...
bbgate.com
- By Heineken
what isomer can get this way made 4mmc?
Similarly 4 MMC also has a chiral carbon and exists as a pair on isomers after synthesis by known and conventional ways.There is literature describing resolution, I don't know by what way, but I would give it a try blind with tartaric or something simillar, I can maybe dig up some articles later tonight when I got time.
Regarding effect the S-isomer seems to be 50x more serotonergic, about crystal structure I can't tell you, maybe find out yourself and tell us.
Regarding effect the S-isomer seems to be 50x more serotonergic, about crystal structure I can't tell you, maybe find out yourself and tell us.
- By alpha2222
thanks,I followed a video of the reduction reaction, make p2np solution 5 grams p2np 50ml of alcohol 20 gaa, sodium hydro. 25g to 75ml of water, foil mercury nitrate, make amalgam, pour in solution, once solution finishes, add lye solution let sit, pull clear, then bring ph to 6 by adding anhydrous acetone and sulfuric acid, stick in the freezer for awhile pull and vacuum filter, dude in video skipped some steps for amalga, but figured that part out, here is another question, I ordered some nitric acid from chemlab says it .01 proof, whenever I mix with mercury to get my nitrate is doesnt do anything, no reaction tried heating does that mean its just not strong enough, and again thanks for answering my questions, I know it was on chuckle for most but really appreciate that...
oh so it's amphetamine we're talking about, ok
Then this changes what I said.
Proof is not a good way to describe concentration, but it sounds like you bought volumetric solution, which means it is very dilute.
You can get around this by taking an equivalent amount of mercury metal and swirl it a lot with 3x3cm aluminium squares in a flask in a vinegar medium, do not use more than 9% acetic acid and occasionally push your squares down into contact with the mercury.After a while there should be little to no mercury left at the bottom and amalgamation should be evident.At that point you drain, skip the rinse for now and add the p2np dissolved in ipa and acetic acid, if you get to this point and manage to isolate an organic layer it is recommended you dry it with MgSO4 anhydrous or wash with some brine.Make sure your sulphuric acid is not also volumetric solution.Use a 1/10 sol of acetone and acid to precipitate salts.
For precipitation you can do yourself a favor and skip the sulfuric acid for L-tartaric (wine store). Simply dissolve the solid L-tartaric acid in alcohol with a bit of heat and use as you would use the acetone H2SO4 solution.This will leave you with the tartrate salt of d-amphetamine, the more pharmacologically desirable enantiomer.Tartrate salts are, after all, stable when dry, contrary to what I tought in the past.
Then this changes what I said.
Proof is not a good way to describe concentration, but it sounds like you bought volumetric solution, which means it is very dilute.
You can get around this by taking an equivalent amount of mercury metal and swirl it a lot with 3x3cm aluminium squares in a flask in a vinegar medium, do not use more than 9% acetic acid and occasionally push your squares down into contact with the mercury.After a while there should be little to no mercury left at the bottom and amalgamation should be evident.At that point you drain, skip the rinse for now and add the p2np dissolved in ipa and acetic acid, if you get to this point and manage to isolate an organic layer it is recommended you dry it with MgSO4 anhydrous or wash with some brine.Make sure your sulphuric acid is not also volumetric solution.Use a 1/10 sol of acetone and acid to precipitate salts.
For precipitation you can do yourself a favor and skip the sulfuric acid for L-tartaric (wine store). Simply dissolve the solid L-tartaric acid in alcohol with a bit of heat and use as you would use the acetone H2SO4 solution.This will leave you with the tartrate salt of d-amphetamine, the more pharmacologically desirable enantiomer.Tartrate salts are, after all, stable when dry, contrary to what I tought in the past.