Anyone know how to cook MDMA ??
Regardless of what you wanted to start with, I suggest you readThese 32 reactions or workups from the rhodium archive. Pay attention to the chemicals, can you get them? That's the real pinchpoint in most synths. If you can get nitroethane, that will be a deciding factor on the reactions. Or THF . I could probably find that many more in 5 minutes of looking.
Kinda OTC black pepper to MDMA synthesis
Credit to u/CannaTFF over on Reddit, and user archae on BBGate forum
Black pepper to MDMA
https://chemistry.mdma.ch/hiveboard/methods/000321699.html black pepper to MDA
1. Black pepper piperine extraction
place 25g (1) of ground black pepper in a 500mL round-bottomed flask, add 250mL of 99% isopropanol with magnetic stirrer or boiling chips (2), and heat at reflux for 2-4h. Filter the mixture by suction filtration and then concentrate the filtrate to a volume of 10-15mL by simple distillation or by use of a rotary evaporator. to 20mL of a 10% solution of KOH/NaOH in 99% isopropanol contained in a 200ml beaker add the concentrated pepper extract. heat the resulting solution and add water dropwise. a yellow precipitate forms. add water until no more solid appears to form and then allow the mixture to stand at least overnight in a fringe 3-4 Celsius (3). collect the solid by suction filtration and recrystallize it with 20-30mL of isopropanol (4). (1) this extraction may be scaled up to twice the amounts specified without difficulty. If a Soxhlet extractor is available, this would be an apparatus superior to a standard reflux setup. (2) magnetic stirring or boiling chips are necessary to prevent serious bumping. (3) it is best to allow piperine to completely precipitate out by allowing the mixture to stand until the next laboratory period. (4) in our hands ca. 1-2g of piperine, mp 127-128°C, was collected upon recrystallization.
https://erowid.org/archive/rhodium/chemistry/3base/piperonal.pepper/piperine.pepper/index.html
100g of pepper = 4g-8g of piperine
(Recommendation) to buy piperine supplement powder from eBay or Bezos(amazon)
2. Hydrolysis of Piperine to Piperic acid
(2) Hydrolysis of Piperine to Piperic Acid: (These instructions are in the small scale, obviously they can be increased) Heat mixture of 0.1g piperine and 10ml of 2M ethanolic potassium hydroxide under reflux for 1.5h. Evaporate the ethanolic solution to dryness under vacuum. Suspend the solid potassium piperate that remains in the flask in about 5ml of hot water and carefully acidify the suspension with 6M HCL. Collect the precipitate, wash with cold water, recrystallize from COLD ethanol. The mp of the product should be around 206C (a little less than the literature values due to the slight Chavacine impurification (Chavacine is the Z, Z isomer of piperic acid (E, E))
75-85% theoretical yeild
http://www.sciencemadness.org/talk/viewthread.php?tid=4465
Oxidation of Piperic acid to piperonal
Materials5g piperic acid16.9g NaOH25.6g CuSO4* 5H2O150mL DCM205mL H2Osuff. HCl(aq) to acidifyProcedure
https://chemistry.mdma.ch/synthforum/about417-0-asc-0.html
https://erowid.org/archive/rhodium/chemistry/nitroethane.html
https://www.prepchem.com/synthesis-of-nitroethane/
Conversion of Piperonal to MDP2P
https://bitnest.netfirms.com/Rhodium/chemistry/mdp2np.html direct-ish to MDP2NP
Piperonal 35g = 30g of MDP2NP = 15g of MDP2P
https://erowid.org/archive/rhodium/chemistry/mdp2p.piperonal.html decent mdp2p
Piperonal 35g = 31g of 2 nitroisosafrole =21g of MDP2P (highest yield)
https://chemistry.mdma.ch/hiveboard/novel/000399715.html MDP2NP=MDP2P
Piperonal 35g = MDP2NP 37g= 18g MDP2P
MDP2P to MDMA
https://chemistry.mdma.ch/hiveboard/newbee/000531792.html
https://erowid.org/archive/rhodium/chemistry/redamin.os-bs.html
Credit to u/CannaTFF over on Reddit, and user archae on BBGate forum
Black pepper to MDMA
https://chemistry.mdma.ch/hiveboard/methods/000321699.html black pepper to MDA
1. Black pepper piperine extraction
place 25g (1) of ground black pepper in a 500mL round-bottomed flask, add 250mL of 99% isopropanol with magnetic stirrer or boiling chips (2), and heat at reflux for 2-4h. Filter the mixture by suction filtration and then concentrate the filtrate to a volume of 10-15mL by simple distillation or by use of a rotary evaporator. to 20mL of a 10% solution of KOH/NaOH in 99% isopropanol contained in a 200ml beaker add the concentrated pepper extract. heat the resulting solution and add water dropwise. a yellow precipitate forms. add water until no more solid appears to form and then allow the mixture to stand at least overnight in a fringe 3-4 Celsius (3). collect the solid by suction filtration and recrystallize it with 20-30mL of isopropanol (4). (1) this extraction may be scaled up to twice the amounts specified without difficulty. If a Soxhlet extractor is available, this would be an apparatus superior to a standard reflux setup. (2) magnetic stirring or boiling chips are necessary to prevent serious bumping. (3) it is best to allow piperine to completely precipitate out by allowing the mixture to stand until the next laboratory period. (4) in our hands ca. 1-2g of piperine, mp 127-128°C, was collected upon recrystallization.
https://erowid.org/archive/rhodium/chemistry/3base/piperonal.pepper/piperine.pepper/index.html
100g of pepper = 4g-8g of piperine
(Recommendation) to buy piperine supplement powder from eBay or Bezos(amazon)
2. Hydrolysis of Piperine to Piperic acid
(2) Hydrolysis of Piperine to Piperic Acid: (These instructions are in the small scale, obviously they can be increased) Heat mixture of 0.1g piperine and 10ml of 2M ethanolic potassium hydroxide under reflux for 1.5h. Evaporate the ethanolic solution to dryness under vacuum. Suspend the solid potassium piperate that remains in the flask in about 5ml of hot water and carefully acidify the suspension with 6M HCL. Collect the precipitate, wash with cold water, recrystallize from COLD ethanol. The mp of the product should be around 206C (a little less than the literature values due to the slight Chavacine impurification (Chavacine is the Z, Z isomer of piperic acid (E, E))
75-85% theoretical yeild
http://www.sciencemadness.org/talk/viewthread.php?tid=4465
Oxidation of Piperic acid to piperonal
Materials5g piperic acid16.9g NaOH25.6g CuSO4* 5H2O150mL DCM205mL H2Osuff. HCl(aq) to acidifyProcedure
- Combine piperic acid, NaOH, CuSO4 * 5H2O, and H2O.
- Reflux for 8 hours.
- Collect liquid via suction filtration, discarding solids.
- Acidify with HCl(aq).
- Extract product with 3x50mL DCM.
- Distill extract to recover DCM, if desired.Yield: 4.5g piperonal
https://chemistry.mdma.ch/synthforum/about417-0-asc-0.html
https://erowid.org/archive/rhodium/chemistry/nitroethane.html
https://www.prepchem.com/synthesis-of-nitroethane/
Conversion of Piperonal to MDP2P
https://bitnest.netfirms.com/Rhodium/chemistry/mdp2np.html direct-ish to MDP2NP
Piperonal 35g = 30g of MDP2NP = 15g of MDP2P
https://erowid.org/archive/rhodium/chemistry/mdp2p.piperonal.html decent mdp2p
Piperonal 35g = 31g of 2 nitroisosafrole =21g of MDP2P (highest yield)
https://chemistry.mdma.ch/hiveboard/novel/000399715.html MDP2NP=MDP2P
Piperonal 35g = MDP2NP 37g= 18g MDP2P
MDP2P to MDMA
https://chemistry.mdma.ch/hiveboard/newbee/000531792.html
https://erowid.org/archive/rhodium/chemistry/redamin.os-bs.html
- By G.Patton
https://bbgate.com/threads/extraction-of-piperine-with-subsequent-synthesis-of-piperic-acid-and-its-unsuccessful-oxidation-to-piperonal.7334/
Has anybody tried nitroethane from the above.!!
Nitroethane from Sodium Ethyl Sulfate, K2CO3, NaNO2
chemistry.mdma.ch