Phencyclidine (PCP) & Marijuana
Phencyclidine (PCP) primarily acts as an NMDA receptor antagonist in the brain. By blocking these receptors, PCP disrupts the normal functioning of glutamate, a neurotransmitter responsible for sending signals in the brain. This disruption can lead to hallucinations, altered perceptions of reality, and feelings of detachment from oneself and one's environment.
PCP can produce a range of effects, including euphoria, feelings of invulnerability, hallucinations, paranoia, and aggressive behavior. At higher doses, it can lead to muscle rigidity, seizures, and coma.
PCP is known for its unpredictable effects. It can lead to violent behavior, self-harm, and even suicidal thoughts. Chronic use can result in memory problems, depression, and weight loss.
Marijuana's psychoactive effects are primarily due to delta-9-tetrahydrocannabinol (Δ9-THC or THC), which is a partial agonist for cannabinoid receptors CB1 and CB2 in the body. Cannabinoid receptors are part of the endocannabinoid system, which plays a role in regulating various physiological and cognitive processes. Marijuana also contains cannabidiol (CBD) and over 400 other compounds, with each potentially having individual and interactive effects that contribute to the net effect of marijuana.
Cannabis can produce relaxation, euphoria, altered sensory perceptions, increased appetite, and impaired memory and concentration.
While marijuana is generally considered less harmful than many other drugs, it can lead to impaired judgment, coordination issues, and potential dependence. Chronic use can result in cognitive deficits and mental health issues like anxiety and depression.
The exact mechanisms of interaction between PCP and Marijuana when combined aren't thoroughly documented, but the combination is known to be dangerous. It can lead to significant adverse effects. Some of the observed effects include:
- Hallucinations and Delusions: Both substances have hallucinogenic properties, which might be amplified when used together.
- Confusion and Aggression: The dissociative effects of PCP might be intensified with marijuana use, leading to confusion, and potentially aggressive behavior.
- Risky Behaviors: The altered judgment and perception caused by these substances might lead to engagement in risky behaviors.
- Seizures: The combination might affect the central nervous system to a degree that induces seizures.
- Potential Serious Neurological Conditions: Long-term or heavy use might result in serious neurological issues.
- Long-term use of PCP-laced weed can result in lung problems, heart attack, loss of muscle tissue, brain damage, disrupted growth in young adults, coma, and potentially some types of cancer.
The combination, known by street names like "killer joints," "supergrass," "fry," "wet weed," or "dusted weed," underscores the dangerous nature of mixing these substances.
There doesn't appear to be any recognized profits from combining PCP and Marijuana. Both substances individually carry risks (especially PCP) and when combined, these risks are likely exacerbated. The euphoric or hallucinogenic experiences some individuals seek from such combinations come with serious health and safety hazards.
We did not encounter reliable, verifiable, and repeated information about acute emergency conditions associated with this combination.
Considering the above, we recommend treating this combination with great caution.
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