Amphetamine Amphetamine synthesis by P2NP with NaBH4/CuCl2 ( Quantity 1 POT/1 KG )

Reaction diagram

Reagents Isopropyl alcohol (IPA) - 20 L. Distilled water - 6.2 L. Sodium tetrahydruroborate (NaBH4) - 1739 g. P2NP - 1000 g. Copper(II) chloride - 105 g. Sodium hydroxide (NaOH) aqueous solution 25% - 8 L. Dry acetone - 2.5 L. Sulfuric acid (or Phosphoric acid).

Equipment and Glassware Batch reactor (measuring range: 50 L) equipped with reflux condenser, top stirrer and in-line heating system; Nutsche filter; Laboratory balance (1-2000 g); pH indicator paper; Several buckets for 10 and 20 L; Laboratory thermometer ( Measurement range: 150 °С); Freezer; Pyrex dishes for crystallization; Graduated test tube for 1 L; Conventional funnel; Drop funnel; Vacuum pump; 2 Beakers for 5 L; Acid cold water bath for reflux condenser;

Synthesis procedures A 2:1 mixture of IPA and water (18 L) is added to the batch reactor. Solid NaBH4 (1739 g) is added to a portion and the stirrer is started. Pure P2NP (1000 g) is added in several small portions to keep the mixture below 60°С. A CuCl2 solution (105 g) in water (200 ml) is slowly added drop by drop to keep the mixture below 80°С. The reaction is then kept at 80°C for 30 minutes with the help of an external radiator. NaOH (8 liters 25%) in aqueous solution is added to the chemical reaction and the layers are separated. The aqueous phase is extracted with 8 liters of IPA. The amphetamine is dissolved in the IPA, and the density of the IPA layer changes as it is separated from the aqueous solution layer. The IPA extract from step 7 evaporates using the vacuum pump to arrive at a neutral amphetamine base oil combined with that from step 6. The neutral amphetamine base oil is dissolved in 2 L of dry acetone. Sulfuric acid (or phosphoric acid) is added drop by drop to reach a pH of 6 (in constant mixture). The mixture is then placed in a refrigerator for 12 hours. After the crystallization procedure in the refrigerator, the amphetamine salt suspension is filtered through a Nutsche filter and then cleaned with cold dry acetone to obtain a whitish color. The acetone from the cleaning procedure can be crystallized as described in steps 11-12 (but the quality of the amphetamine salt will be reduced). The yield is 60-70%.

P2NP (Image 1); CuCl2 (Image 2); CuCl2*2H2O (Image 3)

Amphetamine synthesis

• Novator
• Apr 4, 2023
• 55

Amphetamine synthesis via NaBH4 reductive amination from P2NP...

Source: @GhostChemist ( /threads/one-pot-amphetamine-synthesis-from-p2np-with-nabh4-cucl2-1kg-scale.70/)

 

[ase]

A oil for sale in europe?

 

[Magicshroom]

magnifique, merci pour ce joli poste!