LSD synthesis video

[psy]

Hello friends,
I have been planning a synthesis of LSD for a little while. If you would like to see this, let me know. Odds are, I am going to do it anyway, with or without a camera recording, so I am trying to figure out if it is worth the hassle. The synthesis would be on a 100mg scale, starting from cafergot pills. The ergotamine would be extracted with ethyl acetate/hexanes, and separated by column chromatography from the other ingredients within the pills. It will be hydrolyzed a la Shulgin to lysergic acid. It will then, be reacted with diethylamine with a peptide coupling reagent. Followed by workup to get LSD. I am not going to bother with the tartrate salt as I don't intend to purify it past this point.

If you'd like to support this project you can buy some magic powders from me. If I get enough orders or enough interest, I will do it. Sorry to blue ball you all with an advertisement, but I can't do this all for free unfortunately.

For those who think I am full of shit:

 

[HEISENBERG]

We are willing to buy a synthesis video from you if it is done well. Contact our experts if you are interested in the offer.

 

[diogenes]

That would be so cool, especially if explanations/advice is added to each step (e.g. what to look out for, how to prepare each material etc.). I would contribute to buying such video, Heisenberg, let me know if the deal is going ahead.

 

[psy]

It is currently being worked out; however I could show how to dry DCM with phosphorus pentoxide, synthesis of the catalyst for the peptide coupling reaction, freebasing the diethylamine from its salt, how to run a column, brief explanation on extractions, etc...
It is advanced chemistry but I could do my best to present it in a way most will understand.

 

[amieri]

Any progress? I've been patiently checking this for months now hoping for a update

 

[Wario]

This would spread love around the world

 

[eu.lab]

Any new update on the Video?

 

[HerrHaber]

I also plan making it even if I may not be the first to publish it... I hope it will be good. I need a rotavap machine only since I have the glasssware for it, I also lack stirrers and stands with clamps maybe a large sep funnel. Looking forward to find the proper place. I was thinking of revealing my face when explaining but my favorite band is Sleep Token, masks and no one knows anything about them. I may adopt a vessel (sleep token member) identity that I will distort putting a Hannibal Lecter mask.

 

[HerrHaber]

Not a drop of the resulting acid will be sold!!!.... This is how I mean it. Late period I ran pretty poor and hours ago I got jobless. I have young future me in training and I help everyone for free on this forum even if I know it brigs big money to them due to my advice. I am willing to accept help in any form be it reagents (especially diethylmonomethulamine which is expensive to buy a pack) a vial of 5-10mL is costly with respect to most small amines, equipment was stolen from my former two attempted trainees as well as vacuum pump and some cool glassware.

 

[eu.lab]

This is the moment where HerrHaber becomes Heisenberg.
Jokes beside I suggest you to give the acid to "investors" that fund chemicals for your video. Its a win-win for everyone. The forum gets a video that helps people, you'll be able to produce the video without much funding of your own and the people funding the chemicals get a bit of return. 1-2g LSD would be enough for 5000x 200uq trips, enough to supply every investor with a good amount of acid.
Also BB Forum might give you a bit money for the video material.

Hope your situation gets better, I know the struggle myself.

Cheers

 

[PsychedelicDog]

@HerrHaber could you come up with a rough estimate of how much founding is needed?

 

[HerrHaber]

I had been doing some calculations and I thank you for this question because I’m having the revelation of not knowing even a rough estimate of what it costs. The situation is such that I can calculate equipment, chems, time and chemistry but I should also include the place for example. Over all I am a bit surprised that getting the “acid” moiety is like the third most costly material after the asymmetric amine and PyBOP. Approaching this by the direct condensation of the acid resulting from the methyl ester in situ hydrolysis is just too tempting not to try. On the other hand destruction of chirality is a key point to consider in not overreacting, which in preparative quantity may be well worth it but it sounds so much 2023 to post the procedure as stereoselective. I am well aware of the fact that racemic resolution can be accomplished both via chiral chromatography and diastereoselective salt formation with optically pure acid such as tartaric acid. Even if the racemization is historically the way to go and it is worth it knowing that maximal yield is 50%.