Ketamine & Mephedrone
Ketamine and Mephedrone are both psychoactive substances that affect the central nervous system in different ways. Ketamine is a dissociative anesthetic that is commonly used for pain relief and sedation, while Mephedrone is a synthetic stimulant that produces effects similar to some extent to MDMA and other euphostims.
Ketamine is categorized as a non-competitive antagonist of the NMDA receptor which is a glutamate receptor. This receptor plays a crucial role in allowing electrical signals to pass between neurons in the brain and spinal column. Dissociatives like ketamine work by blocking NMDA receptors, which leads to disconnection between neurons and can cause loss of feeling, difficulty moving, and the well-known state called the "K-hole". This mechanism of action also produces dissociative or hallucinogenic effects, which can be desirable for recreational use but can also be disturbing or disorienting.
At high doses, Ketamine has been found to bind to μ-opioid receptors, but without agonist activity. Additionally, it has been shown to interact with sigma receptors in rats, muscarinic receptors, descending monoaminergic pain pathways, and voltage-gated calcium channels. At both subanesthetic and fully anesthetic doses, Ketamine has been found to block serotonin depletion in the brain by inhibiting 5-HT receptors rather than through monoamine oxidase inhibition.
Mephedrone (4-methylmethcathinone), on the other hand, is a synthetic cathinone that acts as a stimulant by increasing the activity of certain neurotransmitters in the brain. Due to its chemical structure, Mephedrone acts as both a releasing agent and a reuptake inhibitor for monoamine neurotransmitters like serotonin, dopamine, and noradrenaline. This can help explain the euphoric and stimulating effects associated with Mephedrone use. It is often used as a recreational drug due to its euphoric and energizing effects, but it can also cause anxiety, agitation, and psychosis in some users.
When Ketamine and Mephedrone are taken together, they can interact in unpredictable ways, leading to potentially dangerous side effects. The exact mechanisms of interaction are not well understood, but it is believed that the two substances may amplify each other's effects on the brain and body. This can lead to an increased risk of adverse reactions and overdose.
Some potential side effects of Ketamine include nausea, vomiting, dizziness, and changes in blood pressure and heart rate. Mephedrone can cause similar side effects, as well as agitation, anxiety, and paranoia.
Combining ketamine and mephedrone can lead to several dangerous side effects and interactions:
Synergistic effects: The combined use of a dissociative anesthetic and a stimulant may produce an unpredictable and intense experience, increasing the risk of adverse psychological reactions, such as anxiety, paranoia, hallucinations, mania, confusion and disorientation, seizures or convulsions, and even psychotic states/.
Cardiovascular risks: Mephedrone is known to increase heart rate and blood pressure, while ketamine can also have unpredictable effects on the cardiovascular system. The combination may lead to an increased risk of heart-related complications.
Neurotoxicity: Both substances can potentially cause neurotoxic effects. The combination may increase the risk of long-term damage to the brain.
Impaired judgment and coordination: The combination of the dissociative effects of ketamine and the stimulation from mephedrone can lead to poor decision-making, increased risk-taking behavior, and impaired motor control, increasing the risk of accidents and injuries.
Nevertheless, the reviews of those who used this combination with caution, experience, correct set and settings, note the intense and clearly enhanced effect of the substances. Which in turn does not cancel out the dangers listed above.
People note the extreme intensity of the effects in relation to the dosages of substances individually.
To reduce the load on the nasal mucosa, Mephedrone can be taken orally by bombing, which will affect the dosage regimen and timing.
Considering the above, we recommend treating this combination with great caution.
Last edited by a moderator: