Phenibut & SSRIs
Phenibut primarily acts as a GABAb receptor agonist. As the dosage of Phenibut increases, it loses its selectivity for GABAb and gains additional activity as a GABAa agonist. The sedating effects of Phenibut can be attributed to its actions on the GABAb receptor.
Previous research indicates that the administration of Phenibut at a dosage of 25 mg/kg results in a noteworthy elevation in the levels of dopamine metabolite (3,4-dioxyphenylacetic acid) and the inhibitory amino acid taurine in the striatum. However, the impact of Phenibut on the levels of GABA, serotonin, and dopamine in different brain regions was not found to be statistically significant. Interestingly, a moderate decrease in the level of norepinephrine in the hippocampus was observed upon Phenibut administration.
Selective Serotonin Reuptake Inhibitors (SSRIs), on the other hand, work by inhibiting the reuptake of serotonin in the brain. This results in increased serotonin levels, which can improve mood and alleviate symptoms of depression and anxiety.
Some SSRIs: Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline.
The impact of SSRIs on the serotonin receptors can influence GABA-ergic system. An old study on rats showed that SSRI treatment has a slight impact on GABAergic transmission in the hippocampus. Furthermore, SSRIs may have an anxiolytic effect. In combination with Phenibut, which also reduces anxiety, we can expect the development of a synergy effect.
The combination of Phenibut and SSRIs does not have an accurate scientific description at the moment. We have not found any direct acute negative consequences. User reviews, range from extremely positive impressions of this combination (including those who use both substances for a long time) to alarming and extremely negative after the first experience. In the latter, there are mentions of severe anxiety, unpleasant sensations and experiences, frightening illusions, and panic reactions.
However, we must remember the complex and poorly predictable effect on a specific person, they metabolism and the central nervous system of both Phenibut and SSRIs drugs (they also have differences). Plus, the possible synergy of the anti-anxiety effects can result in side reactions in the form of drowsiness, dizziness, headaches and loss of consciousness.
We do not see the potential for recreational use of this combination, however, we assume that in some cases it can be used for medical purposes. In any case, consultation with a doctor and low starting dosages will not be superfluous.
In light of these considerations, we strongly recommend a meaningful approach to this combination.
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