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Now we will look at the synthesis of cannabinoid UR-144.
Requirements for the room:
The working area (a tabletop for cooking product) must be necessarily equipped with exhaust ventilation with the possibility of fresh air inflow. There is no place to be equipped (multi-tiered racks) for drying the product, also with the possibility of air ventilation. It is also worth taking care of the packaging so that the place has enough convenient to weigh and pack, preferably under exhaust ventilation. At the time of production, the floors are recommended to cover with a polyethylene membrane, as such an abundance of cannabinoid dust cannot be avoided. Subsequently, the room will be easier to clean, collecting polyethylene membrane.
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Reagents:
1.
2,2,2,3,3-tetramethylcyclopropyl(1H-indol-3-yl)methanone (TMCP-indole).
2. Sodium hydroxide (NaOH).
3. Tetra-n-butylammonium bromide (TBAB).
4. 1-Bromopentane (1-BP).
5. Water (H2O).
Equipments:
1. Scales.
2. Flat-bottom flasks 10 l.
3. Funnel for bulk materials (with wide bottom).
4. Scoops for flour.
5. Glasses of 1-2 l.
6. Electric burner.
7. Overhead stirrer (not necessary, but better with it).
8. Silicone Baking Molds.
9. Syringes.
10. Blender.
11. Large bowl or bucket.
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Individual protection:
1. Long Sleeve Clothes.
2. Respirator mask (or respirator + glasses).
3. Latex gloves.
4. Fabric gloves or a piece of thick fabric.
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Addition:
1. Weigh 2000 g of the TMCP-indol and add them to 10 l flask through a funnel for bulk materials.
2. Weigh 1300 g sodium hydroxide and add to the TMCP-indol in10 l flask.
3. Weigh TBAB 800 g and also add to 10l flask
4. Pour 1500 g 1-bromopentane into the flask (it is by weight in kilograms, not liters).
5. Pour 3000 ml water (the usual water supply is suitable if it is acceptable).
Reaction:
After we added all the reagents, we mix the reaction mixture until two different layers are separated and the entire hydroxide is dissolved. When it dissolves, the flask will be heated, so as not to burn, you can additionally use the plated gloves, dressed under latex, or thick piece of fabric.
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As soon as two layers were divided and the entire hydroxide was dissolved, put the flask on the tile, and turn the heating to the maximum. If there is an overhead stirrer, install it in the flask, if not, then mix the flask, dressing the tissue gloves or taking thick pieces of fabric (rags, towels), so as not to burn it (at the end of the reaction it will be very hot). It is necessary to mix well enough so that the layers are mixed (homogenized).
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The overhead stirrer can work on constant stirring the entire reaction. If there is no stirrer, then we periodically twist the flask in fabric gloves, constantly if the mixture already boils. The heating at boiling continue until the contents of the flask appear to look as much as possible (several in the "milk" color), without a clear layer dedication (usually 15-30 min passes before).
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Then remove the flask from heating and let it be to a clear separation into two layers. We need the top layer. The product can crystallize directly in the flask, which makes it difficult to extract it. Therefore, we do everything quickly.
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Remove the top layer neatly from the flasks into the glasses (do not forget about the temperature, use thick gloves or towels), or immediately into silicone forms. It is necessary to follow so that the lower water layer remains in the flask. When the upper layer (oil) remains quite small, it can be poured into a glass with water, and carefully collected with a syringe.
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Leave at room temperature by 24 hours until it hardens. We take silicone forms precisely for the ease of extracting the product after crystallization, it fully solidifies and takes the form in which it was poured.
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We take out and crush the crystallized product. Dry on paper and trays. With a warm room and ventilation, drying usually takes two days. Yield: 3000 g.
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We can use this reaction for other cannabinoids JWH series.
