DMT and Its Derivatives: Synthesis Guide and Methods

A Comprehensive Guide to DMT Synthesis: From Tryptophan to 5-MeO-DMT

Dimethyltryptamine, or DMT, is a powerful psychedelic compound known for its intense and unique psychoactive effects. In this comprehensive guide, we will explore various methods of DMT synthesis, including synthesis from tryptophan, the synthesis of 5-MeO-DMT, and the synthesis of 4-AcO-DMT. We will delve into the pharmacokinetics, pharmacodynamics, clinical effects, administration methods, dosages, and laboratory requirements associated with DMT synthesis.

Part 1: DMT Synthesis Methods

DMT can be synthesized using several methods, each with its unique procedures and reagents. Let's explore some of the prominent approaches:

1.1. Synthesis from Tryptophan

Steps in DMT Synthesis from Tryptophan:

  1. Activation of Tryptophan: Tryptophan is activated using a suitable reagent, such as phosphoryl chloride (POCl3), to form an intermediate compound.
  2. Reduction: The intermediate compound is then reduced using a reducing agent like lithium aluminum hydride (LiAlH4) to produce indole-3-ethanol.
  3. N-Methylation: Indole-3-ethanol is N-methylated using a methylating agent like methyl iodide (CH3I) to form DMT.

1.2. Synthesis of 5-MeO-DMT

5-MeO-DMT, a closely related compound to DMT, can also be synthesized using similar methods, with slight variations in reagents and procedures.

1.3. Synthesis of 4-AcO-DMT

4-AcO-DMT, another DMT analog, can be synthesized by acetylation of psilocin, a compound found in certain psychedelic mushrooms. This synthesis involves the use of acetic anhydride.

1.4. Reagents and Equipment

For DMT synthesis, the following reagents and equipment are typically required:

  • Starting Material: Tryptophan for DMT synthesis from tryptophan, and appropriate starting materials for the synthesis of 5-MeO-DMT and 4-AcO-DMT.
  • Reagents: Chemical reagents specific to the chosen synthesis method, including activation and reduction agents.
  • Glassware: Standard laboratory glassware for reaction and purification steps.
  • Safety Equipment: Lab coats, gloves, safety goggles, and a fume hood for safety.

1.5. Laboratory Safety

Working with chemicals and reagents in DMT synthesis necessitates strict adherence to laboratory safety protocols. Proper ventilation, protective clothing, and safety equipment are essential to minimize risks.

Part 2: Pharmacokinetics and Pharmacodynamics

DMT is known for its rapid and intense psychoactive effects. Understanding its pharmacokinetics and pharmacodynamics is crucial for safe and responsible use.

2.1. Pharmacokinetics

  • Absorption: DMT can be administered orally, through smoking, or by intravenous injection. Smoking DMT produces the fastest onset of effects.
  • Distribution: DMT is distributed rapidly throughout the body and can cross the blood-brain barrier.
  • Metabolism: DMT is metabolized primarily by monoamine oxidase (MAO) enzymes.
  • Excretion: DMT and its metabolites are excreted primarily through urine.

2.2. Pharmacodynamics

  •         Psychoactive Effects: DMT is renowned for its intense visual and auditory hallucinations, altered sense of time, and spiritual experiences.
  •         Duration of Effects: The effects of DMT are relatively short-lived, typically lasting 15-30 minutes.

Part 3: Clinical Effects, Administration, and Dosages

3.1. Clinical Effects

DMT is not commonly used for clinical or medical purposes due to its powerful hallucinogenic effects. However, it has gained interest in psychedelic therapy research for its potential therapeutic benefits.

3.2. Administration and Dosages

  • Smoking: DMT is often smoked in its freebase form, with dosages ranging from 20 to 60 milligrams.
  • Oral Administration: Ayahuasca, a traditional Amazonian brew, combines DMT-containing plants with MAO inhibitors for oral ingestion. Dosages vary but are typically higher than smoked DMT.

Part 4: Laboratory Requirements

Conducting DMT synthesis in a laboratory necessitates specific equipment and adherence to safety standards:

  • Fume Hood: Adequate ventilation is crucial when working with chemicals.
  • Safety Equipment: Personal protective equipment, including lab coats, gloves, and safety goggles, is essential.
  • Reagent Storage: Proper storage and handling of reagents to prevent accidents.
  • Waste Disposal: Implement a designated system for disposing of hazardous materials.

Part 5: Conclusion

DMT synthesis involves intricate chemical processes and carries significant risks. Understanding the methods, pharmacokinetics, pharmacodynamics, clinical effects, and safety requirements is vital for those involved in DMT-related research or synthesis. Always prioritize safety and adhere to legal regulations when working with controlled substances.

  1. H

    Tryptamine synthesis DMT

    Is anyone familiar with the synthesis steps of dmt? Can you help me see where I'm going wrong? Experiment 1: 1、tryptamine is dissolved in methanol. 2、add formaldehyde solution of 2 molar equivalent. 3、 add methanol solution of sodium cyanoborohydride. 4、 mix and stir, slowly add glacial...
  2. R

    dimethylamine from dimethylformamide

    I prefer Shulgin's DMT synthesis using oxalyl chloride above all. It's really convenient apart from actually getting dimethylamine, as it is controlled. This video shows how it can easily be made simply, cheaply and in freebase form through hydrolysis of the amide in DMF with NaOH. You just need...
  3. J

    about the effects of DMT

    Hello world, i experienced LSD a while ago and was enjoying seeing how beautiful this world is and who i really am, explored so many things and became hobbies personally. and my roommate told me that DMT is the direct train to experience NDE (Near Death Experience) haha even said the god...
  4. 6tom

    Would this dmt synthesis work

    this synthesis originally came from“Synthesis of DMT (and analogs) from Tryptamine by Rhodium” I extended it more with greater detail I am just asking if I got everything correct since I am not the smartest at chemistry but have performed multiple synths but not in psychedelics. 1.“Dissolve 15...
  5. Gauss

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    I was just wandering what are the most common ways to cause irreversible damage to your cook in way that you can no longer extract DMT from rootbark
  6. BlueFairyDMT

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    Hello I am so glad that I was able to discover this forum Breaking Bad. When I returned to vending dmt again after a 3 year hiatus dread forums went down. Anyways..... Just wanted to shout out some love to everyone. BlueFairy
  7. Agilent1100DAD

    Synthesis of N,N dimethyltryptamine freebase via Fischer Indole (with photos of the process and a video)

    Hope ya'll enjoy! 1. A medium sized magnetic stir bar was inserted into a 500 mL RBG flask. 18 g of phenylhydrazine HCl was dissolved in 250 ml of deionized water in a 500 mL 3 neck 24/40 joint RBF, which is put onto a heating mantel that acts as a magnetic stirrer. Neck 1 had a rubber septum...
  8. A

    Anyone know of plants in Australia that contain DMT?

    I would like to know so I can start extracting it. I think Acacia Longifolia contains about 0.3-0.8% but Im not sure.
  9. S

    My Best Substituted Tryptamines List So Far.

    Substituted Tryptamines 4-PO-DMT (Psilocybin) 4-HO-DMT (Psilocin) 4-HO-MET (Metocin) 4-HO-DET (Ethocin) 4-HO-MiPT (Miprocin) 4-HO-DiPT (Iprocin) What can you say about this?
  10. Albert Hofmann


    INTRODUCTION: N,N-Dimethyltryptamine, commonly known as DMT, is a powerful psychedelic and mostly known for its short duration of action, unlike LSD, DMT effects can last from 15 mintues to 3 hours depending on the way it's taking. DMT can be injected, inhaled, or ingested with "monoamine...
  11. G.Patton

    Australian ayahuasca recipe

    Introduction Ayahuasca, iowaska, ayawaska, and yage all means the same thing. It is a hallucinogenic brew that contains DMT that gives people enlightening experiences that changes lives for the better. People that have taken ayahuasca tea reported astonishing positive effects such as finding out...
  12. G.Patton

    DMT extraction from plants

    Introduction Mimosa hostilis root bark (MHRB) is widely available in powdered form and contains up to 1% DMT. The powdered root bark is usually boiled and taken after a harmine or harmaline containing plant, such as Banisteriopsis caapi or Peganum harmala. Harmine and harmaline are monoamine...
  13. Kai

    need help with extraction of dmt from arundo donax

    İ heard arundo donax contains a good amounth of 5-MeO DMT if i use the same acid, base naptha extraction method on the plant can i be able to get some crystals?
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